Kenéng cóng luxíng zhong shòuyì de lìng yigè rén shì xila de cháng zi, tuoní, ta shì yigè bangpài chéngyuán. Yigè yuè hòu, tuoní bù xiaoxin zài míng ní abo lì si beibù de yitiáo xiao xiàng li qiangshale yi míng niánqing nuzi, dangshí ta cóng yi míng bèi duìshou bangpài chéngyuán zhànling de yi liàng qìche kai qiangdàn qilái. Tuoní de fal? biànhù wo ná chule yi wàn meiyuán. Nà yi nián,1995 nián, dangnián you zhème duo de móusha shìjiàn, women de chéngshì bèi cheng wèi “sharén zhe”. Tuoní yin èr dù móusha zuì bèi dìngzuì, bìng zài zhou jianyù bèi pàn shíwu nián túxíng. Ta shì míngnísudá zhou de dì yigè shàonián, yào chéngwéi yi míng chéngnián rén.
Yòuhuò zài 2006 nián 3 yuè jìnrùle wo de naohai. Yexu shì chuntian háishì zàicì chuxiàn chángqí de xiangfa. Wo ganjué bèi kùn zài yu liányin de hunyin zhong. Ta yizhí jianchí, wo yizhí gei ta ta suowèi de “qizi de lìchang”, dàn wo xiang yào de shì yigè háizi, sìhu wúfa jiechù. Yigè xiánzhì de xiangfa daozhì lìng yigè, wo hen kuài zhìdìngle yigè jìhuà. Zài jiéhun de shíhòu, wo huì zài Craigslist shàng zuò yigè yuànyì hé wo jiéhun de nurén.
Mùqián zuhù zài shíyi yuèdi banqian hòu, xila jìhuà jìnrù wo fángwu de lóu xià danwèi. Bùguò, ta cuòwù de rènwéi zuhù jiàng zài shíyi yuèchu chufa. Xila xiàng dangqián de fángdong tongzhi ta dasuàn banjia. Dang ta yìshí dào ta de cuòwù shí, fángdong tóngyì ràng ta liú xià yigè yuè, rúguo ta zhifùle 1400 meiyuán de zujin. Bùxìng de shì, ta méiyou xiezuò. Fángdong shou dào fatíng de mìnglìng, pòshi ta zài 11 yuè 1 rì banqian. Xila jièzhe zhège mìnglìng, huale ji tian shíjian ba suoyou de wùpin dou zhuang xiang, ba yixie jiajù hé xiangzi cúnfàng zài qíta dìfang, qíyú de dou shì wo jinjí de ràng wo zài gongyù lóu li kong de xiàol? danwèi.

Dàn zìwo yìshí yeyou yigèyu mou zhong lèixíng de luójí xiangguan de lilùn fangmiàn. Rénlèi sixiang bùjin fanyìngle shìjiè, érqie nénggòu genjù yiqián de xiangfa gaibiàn. Wèile dádào zhenli, yigè rén jinglì yigè tuili guòchéng, kaol? dào yiqián de shìjiàn hé lijie, yi dádào mùqián de qíngkuàng. Shèhuì biàn de yuè lái yuè fùzá, yinwèi yiqián de jingyàn yingxiangle xiànzài de yìshí, tuidòng ta cóng jiandan de lùjìng (urweg). Biànzhèng chuansuo chóngxin chuàngjiàn suo xu de tuili guòchéng, yi liaojie zài tèdìng qíngkuàng xià fashengle shénme.

Zhè míng faguan méiyou hé women baochí yuedìng. Women huángùle jiànzhú wù, bìng zhaodào lìng yi míng zhèngzài qingli bàngongshì de faguan John Stanoch. Ta dangchang tóngyì jià gei women. Yu péngyou Harvey hé Julie gòng jìn wucan hòu,Sheila hé wo kaiche dào shèngbaoluó yi nán de yigè duchang jin yín dao. Women xiaoxin dubó, chile yi dùn fàn. Zài huí jia de lùshàng lúntai píngtan, dàn women faxiàn yigè chekù dakai, jiang xiufù ta.


Before and after 2009, all major press groups in Fujian started to establish e-newspapers and transfer the newspaper contents to their official news websites to cope with the loss of readers as a result of the prevalence of computer technology as well as to maintain and expand the influence of traditional media. The popularity of Weibo and WeChat emerged between 2011 and 2012, thereby prompting the local press groups in Fujian to try out both platforms. During this period, newspapers were the pillar of the press groups’ revenue. Within most press groups in Fujian, Weibo and WeChat remained under the operation of newspaper editors and journalists on a part-time basis and received limited emphasis from the leadership.

Wénlín 4.3 bǎn hái wánquán zhīchí Adobe de Han Sans zìtǐ, zhè shì yī zhǒng xīn de Pan-CJK zìtǐ xì (kě miǎnfèi xiàzài), hái gǎijìnle zìtǐ xuǎnzé gōngnéng de yì yòng xìng. Qítā xīn gōngnéng hé shēngjí de gōngnéng bāokuò︰yāsuō MP3 géshi lùyīn; nèi zhì wǎngluò sōusuǒ; xīn de fāyīn, dǎoháng hé lièbiǎo děng zēngqiáng gōngnéng. Wénlín 4.3 bǎn wánquán zhīchí Unicode8 CJK de kuòzhǎn IE zhīchí, ràng Wénlín zhuānshǔ CDL zìtǐ yǐnqíng de wénzì miáoshù zǒngshù dádào 103, 510. Huānyíng fǎngwèn www.wenlinshangdian.com gòumǎi Wénlín 4.3 bǎn, shòujià wéi$99. Fúhé zīgé de yònghù kě xiǎngshòu shēngjí jiàgé. Shēngjí nèiróng de wánzhěng lièbiǎo qǐng cānjiàn: http://tinyurl.com/wen43.
Xila zàicì gòumai fángdìchan, dàn yòu shiqùle. Ta anpái chéngwéi fukàn hei si tíng si shì de háozhái de kanshou. Yicì huò liang cì, dang wo zoule, wo ba wo de gou dài dào nàli, yu xila de gou Rico yiqi zài caodì shàng wánshua. Xila de muqin dangshí ye zhù zài nàli. Xila xuyào cóng wo jiè qián lái zhifù zujin, chéngnuò ta muqin de zujin fèn'é jíjiang dàolái. Bùguò, zhè bi qián zhuan ér zài muqin de judòng zhiqián bèi pài wang kansàsi chéng de lìng yi wèi nu'ér. Wo bèi yíqìle. Zhurén hen kuài jiù gan zoule xila hé ta de jiarén. Ta méiyou wendìng de gongzuò.

Oct. 2018, our paper ‘‘Nonnegative Matrix Factorization for Signal and Data Analytics: Identifiability, Algorithms, and Applications’’, has been accepted in IEEE Signal Processing Magazine as a feature article ! This article talks about intuitions, insights, and most recent results behind NMF identifiability theories. Cool applications of NMF can also be found here.


Treatment with the small-molecule PAR1 antagonist alone did not affect the survival of sporadic ALS iMNs (Supplemental Figure 6, K–P; 6 sporadic ALS patients), but the PAR1 antagonist blocked the ability of 3K3A-APC to rescue sporadic ALS iMN survival (Figure 5I and Supplemental Figure 6, Q–V; 6 sporadic ALS patients). Thus, 3K3A-APC can rescue C9ORF72 and sporadic ALS iMN survival through activation of PAR1.
Guanli gongyù de yi wèi péngyou jinggào wo yào xiaoxin, yunxu bùshì zuhù de rén qùchú zuhù de wùpin. Kenéng zhèngzài qisù. Dang zhulì'an huílái de shíhòu, wo qing ta qianle yi zhang zhi, shàngmiàn xiezhe “wo yijing cóng a shén lìhé bi'er mài gao gé xuke dì nàgè dìfang, ba gongyù li de ji gè sùliào dàizi cóng gongyù li qu zoule.” Rènshì a shén lì, wo yiwéi ta de bànlu huì jùjué zhège yaoqiú. Wo zhunbèi paishè ta xiédài sùliào dài de gongyù de zhàopiàn. Bùguò, zhulì'an gei wo méiyou máfan. Ta hen kuài jiù qianshule zhè fèn shengmíng.
Wo de qizi zài 2011 nián 3 yuè faqi de líhun ànjiàn zhong, méiyou xiàng jingfang bàogào zhipiào wèizào hé dàoqiè chéngwéi yigè zhòngdà wèntí, bèi rènwéi shì jìxù gei wo de “qíngfù” de zhèngjù. Jihu suoyou de péngyou hé shúrén, wo de líhun l?shi hé qíta rén dou rènwéi xila shìgè xiaotou, chúnjié ér jiandan. Wo yinggai jin yiqiè kenéng bìmian ta, yi fángzhi wèilái de dàoqiè.
* “Zhongguo xin yimin he Xinjiapo shehui” 中国新移民和新加坡社会  (New Chinese Migrants and Singapore Society), presented at the Fourth Migration Law Forum on “Law of Exit and Administration, China and the World, in Beijing,” organized The School of Law, Beijing Institute of Technology, Beijing Association of International Law, Centre for China and Globalization, and China Western Returned Scholars Association, 18 November 2012.
Hao xiaoxi shì, ta xiànzài zài fùguó yínháng youyi fèn gongzuò, yigè mei xiaoshí zhifù 15 meiyuán. Ta cóng wo nàli toule qián lái zhifù yínháng fèiyòng. Ta ye zhèngzài jìnrù wojia de lóu xià danwèi, bìng you jinjí yuánzhù zhifù yigè yuè de zujin hé sunhui yajin. Wo zuò chule yigè juédìng. Wo keyi xiàng meiguó yínháng bàogào qizhà xíngwéi bìng shouhuí zijin, ye kenéng jiang xila sòng dào jianyù, fouzé wo keyi jieshòu dàoqiè, xiwàng yiqiè shùnlì. Wo xuanzéle hòu zhe.
Zuìzhong wo cóng zhège bú shufú de qíngkuàng chufa, dàn huale hen cháng shíjian. Jíshi xiànzài, wo zhuyào shenghuó zài wo zìji de shìjiè. Wo de guandian shì shénme ràng wo zài zhèngcháng niánlíng de shíhòu dédào yigè jiatíng shì wo zìji de yìcháng de lìyì jítuán. Zài wo de qíngkuàng xià, liánghao de jiàoyù méiyou daozhì yigè hen hao de gongzuò, zhè jiang shi wo you zigé yu héshì de nurén jiéhun. Zhuyào shi yi shangyè qiánjing youxiàn de xiezuò shengyá wéi zhu. Dang wo chéngwéi kuàijìshi shí, wo kaishi chuyú zhonglì wèizhì, érqie yirán rúci. Dànshì, wo de xiezuò gaishànle. Wo jileile zúgòu de qián lái shushì dì shenghuó.
Dec. 2019: Our paper ‘‘Link Prediction Under Imperfect Detection: Collaborative Filtering for Ecological Networks’’ has been accepted by IEEE Transactions on Knowledge and Data Engineering! This paper is co-authored by Xiao, Eugene Seo, Justin Clarke, and Rebecca Hutchinson, all from EECS at Oregon State! Justin was with us as an undergraduate student by the time of submission, and he is now at UMass for his graduate degree. Congratulations, team!
An intronic GGGGCC repeat expansion in C9ORF72 is the most common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), but the pathogenic mechanism of this repeat remains unclear. Using human induced motor neurons (iMNs), we found that repeat-expanded C9ORF72 was haploinsufficient in ALS. We found that C9ORF72 interacted with endosomes and was required for normal vesicle trafficking and lysosomal biogenesis in motor neurons. Repeat expansion reduced C9ORF72 expression, triggering neurodegeneration through two mechanisms: accumulation of glutamate receptors, leading to excitotoxicity, and impaired clearance of neurotoxic dipeptide repeat proteins derived from the repeat expansion. Thus, cooperativity between gain- and loss-of-function mechanisms led to neurodegeneration. Restoring C9ORF72 levels or augmenting its function with constitutively active RAB5 or chemical modulators of RAB5 effectors rescued patient neuron survival and ameliorated neurodegenerative processes in both gain- and loss-of-function C9ORF72 mouse models. Thus, modulating vesicle trafficking was able to rescue neurodegeneration caused by the C9ORF72 repeat expansion. Coupled with rare mutations in ALS2, FIG4, CHMP2B, OPTN and SQSTM1, our results reveal mechanistic convergence on vesicle trafficking in ALS and FTD.
 “Jiu qiaoxiang de zhuanxing: 1978 zhi 2000 nian zhijian lisan huaren dui Panyu de yingxiang” 旧侨乡的转型:1978至2000年之间离散华人对番禺的影响   (The Transformation of Old Qiaoxiang: Chinese Diaspora’s Impact on Panyu, 1978-2000) in Tan Chee Beng 陈志明, Ding Yuling 丁毓玲 and Wang Lianmao 王连茂 (eds.), Kuaguo wangluo yu Huanan qiaoxiang: wenhua, rentong he shehui bianqian 跨国网络与华南侨乡:文化、认同和社会变迁  (Transnational Networks and Qiaoxiang Areas in South China:  Cultural, Identity and Social Change).  Hong Kong: Hong Kong Institute of Asia-Pacific Studies香港亚太研究所, Chinese University of Hong Kong, 2006 , pp. 303-343.

Starting from the emergence of online newspapers, traditional media departments, particularly their leadership, were rather ‘antagonistic’ against new media departments based on the concerns over newspaper circulation. Nevertheless, the competitive relationship between the two types of departments remained unclear because new media departments were situated in a relatively marginalised position inside the press industry. After media convergence along the dominant path was officially launched, original new media departments have been integrated into the new media centre. Vast financial support, manpower and material investments were put to the new media centres of the Fujian press industry, which had reinforced the position of new media department as a ‘rival’ to newspaper offices.

Because autophagy induction can enhance TDP-43 turnover in motor neurons (26), we wondered whether 3K3A-APC treatment could prevent the cytoplasmic accumulation of TDP-43 in ALS iMNs. 3K3A-APC treatment for 6 days significantly increased the nuclear-to-cytoplasmic ratio of TDP-43 in C9ORF72 and sporadic ALS iMNs to control levels (Figure 3, G–J; 2 controls, 2 C9ORF72 ALS, and 6 sporadic ALS patients). Thus, 3K3A-APC treatment can rescue autophagosome formation, lower DPR levels in C9ORF72 ALS iMNs and rescue DPR-mediated neurotoxicity, and reverse the cytosolic accumulation of TDP-43 in C9ORF72 and sporadic ALS patient iMNs.


La Jolla, Jiāzhōu — Wénlín Yánjiūsuǒ yǒuxiàn gōngsī (SPC) zhèngshì fābù Wénlín Hànyǔ Xuéxí Ruǎnjiàn 4.3 háohuá bǎn (Wénlín Wánzhěngbǎn). Xīn fābù de 4.3 bạ̌nběn wánquán zhīchí wánzhěngbǎn Hànyǔ Dà Cídiǎn suọ̌yǐn, suọ̌yǐn jīngguò gēngzhèng, kuòchōng bìng àn zìmǔ shùnxù páiliè, zuòwéi fùjiā chéngxù kě yǔ Wénlín ABC cídiǎn wánměi rónghé, jǐn shòu 49 Měiyuán. Wénlín ABC HDC suọ̌yǐn ruǎnjiàn bǎn kě ràng yònghù qīngsōng chákàn HDC ruǎnjiàn zhōng dàiyǒu de 350, 000 ge duōyīnjié tiáomù. Wénlín ABC HDC kuòzhǎn chéngxù shì yī zhǒng xiānjìn de yánjiū gōngjù, gòng shōunàle chāoguò 568, 000 ge tiáomù. Tōngguò cānkǎo HDC tiáomù, nǐ kẹ̌yǐ gènghǎo de lị̌jiě hěn duō ABC dāncí (bụ̀lùn shì-fǒu chūxiàn zài HDC). Tóngyàng de, HDC hángàile xǔduō wèi shōulù zài ABC cídiǎn de tiáomù, dàn yǔ ABC cíkù jiéhé qǐlai huì gènghǎo lị̌jiě. ABC+HDC de cházhǎo gōngnéng jīngcháng huì dǎoxiàng xiāngguān xìnxī, wúlùn shì Wénlín zhíjiē lièchū de liànjiē huòshì tōngguò Wénlín xīn tuīchū de wǎngluò sōusuǒ gōngnéng. HDC suọ̌yǐn yǔ ABC Hànyǔ cídiǎn xìliè zhǔbiān Méi Wéihéng (Victor H. Mair) jiàoshòu, (láizì Bīnxīfǎníyà dàxué), xiě dào︰ "Kàndào Wénlín fābùle yǐ dānxiàng páixù zìmǔ suọ̌yǐn wánzhěngbǎn «Hànyǔ Dà Cídiǎn» de diànzǐ bǎn, wǒ fēicháng gāoxìng. Zhè duì chīmí Hànyǔ yánjiū de měi yī gèrén lái shuō quèshí shì yī ge fúyīn".
Dàn zìwo yìshí yeyou yigèyu mou zhong lèixíng de luójí xiangguan de lilùn fangmiàn. Rénlèi sixiang bùjin fanyìngle shìjiè, érqie nénggòu genjù yiqián de xiangfa gaibiàn. Wèile dádào zhenli, yigè rén jinglì yigè tuili guòchéng, kaol? dào yiqián de shìjiàn hé lijie, yi dádào mùqián de qíngkuàng. Shèhuì biàn de yuè lái yuè fùzá, yinwèi yiqián de jingyàn yingxiangle xiànzài de yìshí, tuidòng ta cóng jiandan de lùjìng (urweg). Biànzhèng chuansuo chóngxin chuàngjiàn suo xu de tuili guòchéng, yi liaojie zài tèdìng qíngkuàng xià fashengle shénme.
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