Sep 2017: Try the Python implementation of our large-scale GCCA work ‘‘Efficient and Distributed Algorithms for Large-Scale Generalized Canonical Correlations Analysis’’ published at ICDM 2016. The implementation is by Adrian Benton at Johns Hopkins University, who has been doing interesting works in multiview analysis and natural language processing.
Rénmen keyi jiadìng zài women zìji de rìzi zhèngzài kaifa de jìsuànji jìshù de jichu shàng de dì wu gè wénhuà zhuanbiàn. Zhè bùjin jin shì duì xianqián zhonglèi de diànzi shèbèi de kuòzhan, yinwèi jìsuànji tígongle jiaohù shì, gèxìng huà tongxìn de kenéng xìng. Zài zhè zhong wénhuà zhong, tongguò diànnao jiànpán shurù xìnxi de taoyàn de gèrén qudàile kuan guanjié tingzhòng, tamen zài CD, lìtisheng hé cídài shàng bòfàng de yinyuè lùyin de shengyin. Zhuanmén de lìyì jítuán qudài dàzhòng guanzhòng.
Contextualised within the relationship of state, media and journalists, the current study begins with a brief description of local journalists’ attitude towards new media. Thereafter, the authors discuss how local journalists perceive and evaluate media convergence, disclosing the implementation of the dominant convergence path and its influential mechanism. Consequently, this discussion lays an empirical foundation for exploring the regional diversity of China’s media convergence in the future. The following concrete questions will be discussed:
Indeed, we find that C9ORF72 and these sporadic ALS iMNs share defects in autophagosome formation and the aberrant accumulation of glutamate receptors. We find that an engineered, anticoagulation-deficient form of activated protein C called 3K3A-APC, but not heat-inactivated 3K3A-APC (inactive 3K3A-APC), can restore autophagosome formation in both C9ORF72 ALS/FTD and sporadic ALS iMNs. Interestingly, 3K3A-APC also normalizes glutamate receptor levels in C9ORF72 and sporadic ALS iMNs. As a result of these activities, 3K3A-APC lowers dipeptide-repeat protein (DPR) levels in C9ORF72 ALS/FTD iMNs, and potently restores nuclear TDP-43 localization and the normal survival of both C9ORF72 and sporadic ALS iMNs. We show that the ability of 3K3A-APC to rescue ALS iMN survival is dependent on its ability to activate protease-activated receptor 1 (PAR1), identifying PAR1 as a therapeutic target for both C9ORF72 and sporadic ALS. Importantly, 3K3A-APC also rescues glutamate receptor levels and proteostasis impairments in vivo. Thus, motor neurons from C9ORF72 and at least a subset of sporadic ALS patients share common defects in autophagosome formation and glutamate receptor homeostasis, and pharmacologic rescue of these defects by PAR1 activation may slow or prevent neurodegeneration in a substantial fraction of ALS cases.
On the event of the shipwreck in the Yangtze River last year, I sent (passengers’ identity numbers) to the editor-on-duty of the website. He said, ‘Tell me the number of (Fuzhou) people’. I told him he could roughly estimate the number by counting those identity numbers starting with ‘35’. He said, ‘You might as well help me count’. I was being busy on the spot. And I was expected to be the one managing such trivial matters! (Interviewee No. 14)
Lā Qiáolā (La Jolla), Jiālìfúníyàzhōu -- Wénlín Hànyǔ Xuéxí Ruǎnjiàn hé CDL zìtǐ jìshù de kāifāzhě -- Wénlín Yánjiūsuǒ, yóu yī jiā pǔtōng qǐyè (gōngsī) zhuǎnxíng chéngwéi “shèhuì mùdì gōngsī” (SPC gōngsī). Tāngmǔ Bìxiǎopǔ (Tom Bishop) zhǔxí jiěshì le zhè yī juédìng: “Wǒmen de jiàoyù shǐmìng, cǐkè, zài fǎlǜ shang, chéngwéi le wǒmen cúnzài de gēnběn yìyì. Zhè yī xīn dìngwèi wèi ràng gèngduō de rén cānyù dào wǒmen de zǔzhī zhōng pūpíng le dàolù, tóngshí jiāng wǒmen de fāzhǎn tíshēng dào xīn de shuǐpíng. Xiànzài wǒmen yǒuquán yě bìxū zài wǒmen gōngsī de zhāngchéng zhōng guīdìng: jiàoyù jí qítā shèhuì mùdì shì wǒmen de zuìgāo zōngzhǐ.” Chúle yào kuòchōng yī zhī yōuxiù tuánduì, bāokuò cídiǎn biānzuǎn, yǔyánxué, biānchéng hé jiàoyù de dǐngjiān zhuānjiā, Wénlín Yánjiūsuǒ Gōngsī SPC dǎsuàn bǎ cídiǎn hé qítā xuéxí cáiliào fābù dào wǎngshàng, ràng quánqiú fúhé zīgé de gòngxiànzhě kěyǐ xiézuò gǎishàn bìng xiūzhèng Zhòng-Yāng zīyuánkù. Gōngsī de xīn dìngwèi biǎomíng línjìn fābù de Wénlín Hànyǔ Xuéxí Ruǎnjiàn 4.2 bǎn jiāng yǔ zhòngdà shēngjí hòu de gōngsī wǎngzhàn tóngbù lóngzhòng tuīchū.
For all experiments, sample size was chosen using a power analysis based on pilot experiments that provided an estimate of effect size (http://ww.stat.ubc.ca/~rollin/stats/ssize/n2.html). Mice used for immunohistochemical analysis were selected randomly from a set of genotyped animals (genotypes were known to investigators). Mouse tissue sections used for immunohistochemical analysis were selected randomly. The sections were only not used if immunostaining failed. For iMN survival assays, iMNs from 3 biologically independent iMN conversions were used to generate the Kaplan-Meier plot shown. iMN survival times were confirmed by manual longitudinal tracking by an individual who was blinded to the identity of the genotype and condition of each sample. To select 90 iMNs per condition for analysis,more than 90 neurons were selected for tracking randomly using the images from day 1 of the assay. Subsequently, the survival values for 90 cells were selected at random using the RAND function in Microsoft Excel. For quantification of immunofluorescence, samples were quantified by an individual who was blinded to the identity of the genotype of each sample. All other quantification was performed by individuals blinded to the identity of each sample.
Zhu dí hé wo dùguòle yigè xiàwu, bìngqie zài wanshàng de yiduàn shíjian li tánlùnle gè zhong gè yàng de shìqíng. Women shìtú zuò'ài, dàn wo bùnéng. Jianféi hòu, ta de pífu songdòng dì guà zài shenshang, fangfú chuanzhuó xiàngjiao shi de xizhuang. Ránhòu túrán jian, wo faxiàn ta zài dìban shàng chàndouzhe yixie jiná. Shì shí zhèngmíng, zhè shì jiujing xiaofèi dài lái de zhènchàn. Zhu dí zài bingxiang li faxiànle yi píng jiu, dào kongle. Ta xiànzài yào wo jiào jiùhù che ba ta dài dào yiyuàn. Xiangfan, wo ba ta de shì zhongxin kai dàole shèngbaoluó·la mu qí yiyuàn, ràng ta jianchále yi gè danwèi lái zhìliáo ta de bìngqíng. Zhu dí zài xià zhou dùguò.
We thank the NINDS Biorepository at Coriell Institute for providing the cell lines used for this study. Whole-genome sequencing was provided by the University of Washington Center for Mendelian Genomics (UW-CMG) and was funded by NHGRI and NHLBI grants UM1 HG006493 and U24 HG008956 and by the Office of the Director, NIH, under award number S10OD021553. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. We thank Emily Wong and Anton Valouev for assistance with whole-genome sequencing and analysis. We thank Helen Falk and Sandy Falk of Ji Informatics for performing RNA-Seq analysis. We thank USC Libraries Bioinformatics Service for assisting with data analysis. We thank the Choi Family Therapeutic Screening Facility for chemical screening support and DRVision LLC for imaging support. 3K3A-APC was a gift from ZZ Biotech. This work was supported by in part by NIH grant NS090904 to BVZ and startup funds to BVZ. This work was also supported by NIH grants R00NS077435 and R01NS097850, US Department of Defense grant W81XWH-15-1-0187, and grants from the Donald E. and Delia B. Baxter Foundation, the Tau Consortium, the Frick Foundation for ALS Research, the Muscular Dystrophy Association, the New York Stem Cell Foundation, the Alzheimer′s Drug Discovery Foundation, the Association for Frontotemporal Degeneration, the Pape Adams Foundation, the John Douglas French Alzheimer′s Foundation, the Harrington Discovery Institute, the Merkin Family Foundation, the USC Keck School of Medicine Regenerative Medicine Initiative, the USC Broad Innovation Award, the University of Southern California Alzheimer′s Disease Research Center, and the Southern California Clinical and Translational Science Institute to JKI. JKI is a New York Stem Cell Foundation-Robertson Investigator. KAS was supported in part by a Muscular Dystrophy Association development grant.
Liù nián qián, wo faxiàn zìji chuyú jiéhun zhuàngtài, dàn xianrán wúfa yu wo xiànzài de qizi yiqi sheng háizi. Wo kaishi rènshì dào, zài wo de qíngkuàng xià, hunyin shì yigè zuzhi wo chéngwéi fùqin de jigòu, ér bùshì yigè cùjìn fùqin shenghuó de jigòu. Zhè bùshì duì hunyin yinggai shì shénme de waili? Wo yiwéi shì zhèyàng, suoyi wo ba shìqíng jiao geile wo zìji de shou. Wo kaishi xúnzhao jihuì chéngwéi hun wài de fùqin. Jianchí shèhuì gongyue duì wo lái shuo yìyì bù dà. Wo shengmìng zhòng shèng xià de shíjian youxiàn. Wo bùdé bù caiqu xíngdòng.
A doxycycline-inducible (Dox-inducible) NGN2, ISL1, LHX3 (NIL) polycistronic construct was previously integrated into the AAVS1 safe harbor locus of the C9-ALS patient iPSC line using CRISPR/Cas9 editing (4). Dox-NIL iMNs were generated by plating at approximately 25% confluence on Matrigel-coated plates and adding 1 mg/mL Dox in N3 media plus 7.5 μM RepSox 1 day after plating. Mouse primary mixed glia were added to the cultures on day 6, and Dox was maintained throughout conversion. iMN cultures were harvested on day 26.
Zhè shì yigè wo xiang yào yongyou zìji de háizi de jianchí bù lizhì de zìsi de gùshì. Wo de yìsi shì yigè shengwù ér bùshì shouyang de háizi. Dang wo jiéhun yijing you háizi de fùnu shí, wo céng liang dù shì fùqin. Yigè you qi gè háizi - wu gè niánqing rén, liang gè zài tamen de qingshàonián shíqí - lìng yigè you yigè nu'ér lí dàxué yi nián. Suirán wo ba zhèxie dou dàng zuò wo jiatíng de yibùfèn, dàn tamen de muqin bi zhège háizi de fùmu duo yigè, wo xiwàng zhège shì píngdeng de.
Whereas the day-to-day operation of the new media outlets are gradually involved into the political orbit of the Chinese media system, there is a barrier to the convergence which arises from the competitive relationship between the traditional and new media departments for more resources and market rewards yet to be surmounted. The new media centre has difficulty in gaining the support of newspapers, particularly metropolis newspapers in content production, which may accelerate the adjustment of the administrative structure within the local press industry.
Zeng, X., & Liu, Q. (2012). Wangluo duomeiti huangjingxia ligonglei daxuesheng yingyu xuexi jiaolv yanjiu: Jiyu wangluo jiaoxue mushi yu chuantong jiaoxue moshi de duibi yanjiu [A study of English learning anxiety of science and engineering college students under multi-media environment: Based on the comparison of multi-media and traditional classroom teaching]. Waiyu Dianhua Jiaoyu [Computer-Assisted Foreign Language Education], 9, 50–55.Google Scholar
Zhège nurén, xila, shì yigè xidú zhe, bù shì zuhù, ér shì dang yin junzi zàichang shí jingcháng guanggù jími gongyù de rén. Ta hái you ji gè háizi. Zuìxiao de ai li ka, yigè yuè qián jiù chushengle. Xila hé wo hen kuài chéngwéi xìng bànlu. Yinwèi shuìjiào de háizi zhèngzài zhànjù suoyou de chuángwèi, suoyi women shouxian zài míng ní abo lì si beibù de zufáng li zhànle qilái. Gèng duo de shíhòu, women zài 1702 Glenwood Avenue de lóu shàng danwèi zài chuángshàng zuò'ài. Xila youshí zài nàli guòyè. Women keyi zài wanshàng háishì qingchén zuò qìyue.
iMNs from 3 of 6 sporadic lines also had significantly fewer LAMP2+ vesicles than control iMNs, and 3K3A-APC treatment rescued the number of lysosomes in these lines (Figure 2F and Supplemental Figure 2, M and Q). Thus, iMNs from some, but not all sporadic ALS lines display low lysosome numbers. However, for those that do show low lysosome numbers, 3K3A-APC can rescue this phenotype.
* “Xingsu lisan wenxue dianfan: Lin Xingqian shizuo yanjiu” 形塑离散文学典范：林幸谦诗作研究 (Shaping A Model of Diasporic Literature: A Study of Lin Xingqian’s Poetry), presented at the International Conference on “Criticism and Study of Poetry”, in Beijing, organized by the Institute of New Chinese Poetry, Beijing University, and the Research Center of Chinese Poetry, Capital Normal University, 20-21 October 2012.
Women de diànzi yóujiàn taolùn jìnzhan dào ta ba fùjìn de kafei diàn mìngmíng wèi huìyì dìdian. Zhiyou women yuehuì de shíjian dì yi cì jiànmiànle. Wo fachule yigè xúnwèn, dàn méiyou huífù. Si ba dá zhànshìtúrán chénmò yexu ta de zhàngfu yijing liaojie dào women de mìmì duìhuà, bìng caiqu bùzhòu zuzhi huìyì. Yexu ta zhèngzài hé wo yiqi wán wúlùn rúhé, zài fasòng chóngfù de xiao xí zhihòu, wo zài ye méiyou cóng zhège nurén nàli ting dào.
Mihalache, I. 2013. The Importance of Social Dynamics and Continuous Learning for an Efficient Use of Translation Technologies. In Proceedings of Society for Information Technology & Teacher Education International Conference, ed. R. McBride, and M. Searson, 775–788. New Orleans, Louisiana, United States: Association for the Advancement of Computing in Education (AACE).Google Scholar
* “Fuyu wankang de gongminxing: Lu Yutao shizuo de tezhi he celue” 负隅顽抗的公民性：吕育陶诗作的特质与策略 (The Resistance of A Besieged Citizenship: Characteristics and Strategies of Looi Yook Tho’s Poetry), presented at the International Conference on “Modern Malaysian Chinese Poetry: Era, Canon, Localization,” in Kampar, organized by the Institute of Chinese Studies, Universiti Tunku Abdul Rahman, 7-8 July 2012.
Yu xilà rén bùtóng, babilún hé aijí xuézhe bìng méiyou shàngsheng dào guangyì zhishì de shuipíng. Xiangfan, tamen jìlùle jìnxíng jìshù gongzuò de zhúbù chéngxù, wúlùn shì shùxué, yixué háishì jixiè gongchéng. Tamen bianzhìle cíhuì, yàocái, gongkai jìng bài huò zhanbu de wénben hé tianwén guanchá dì lièbiao. Zhèxie xuézhe shì jiang shumiàn zhishì yìngyòng yú shíjì mùdì de jìshù rényuán. Lilùn lùnzhèng hé zhèngjù hái bùdé ér zhi.
N.J.K. and M.S.H. designed experiments, collected data, and wrote the manuscript. D.W.M. analyzed and performed statistics on screen data. A.J. helped design experiments for primary-neuron screens. A.L. and J.O. assisted with cloning. R.M. and G.B. contributed to primary-neuron experiments. J.C. contributed to RNA-sequencing analyses. C.K.T. contributed to the RAB7A-knockdown cell experiments. N.T.H. and M.T.-L. contributed to the dorsal root ganglia experiments. Y.S. and J.K.I. contributed to the ALS iMN experiments. M.C.B. and A.D.G. supervised the study and wrote the manuscript.
“Setting a Role Model: Hong Kong Migrants in Singapore,” presented at The 4th International Conference of Institutes & Libraries for Chinese Overseas Studies on “Interaction and Innovation: Multidimensional Perspectives in Chinese Overseas Studies,” in Jinan University, Guangzhou, organized by Academic of Overseas Chinese Studies in Jinan University, Jinan University Libraries, Ohio University Libraries, 9-11 May 2009.
Yousan gè zhèyàng de zuhù. Wo zài tóngyi tian xiàwu xiàng tamen fachule quzhú tongzhi. Yi míng míng jiào jími de heisè zu kè, zhànjùle dàlóu de dì yi gongyù, xianrán shì yi míng dúfàn. Wo jingcháng kàn dào ta zhàn zài jiejiao, bàngqiú mào zhuan guòtóu lái, ràng gè zhong gè yàng de rén yi lèisì shengyì de jiaotán fangshì jìnxíng jiaoliú. Jími shì dàibu jìlù de rén zhi yi. Wo xiàle ta de danwèi, qiao mén, dì gei ta de quzhú tongzhi, jieshì shuo wo zhèngzài quzhú dàibu jìlù de rén.
Hexanucleotide-repeat expansions in the C9ORF72 gene are the most common cause of amyotrophic lateral sclerosis and frontotemporal dementia (c9ALS/FTD). The nucleotide-repeat expansions are translated into dipeptide-repeat (DPR) proteins, which are aggregation prone and may contribute to neurodegeneration. We used the CRISPR–Cas9 system to perform genome-wide gene-knockout screens for suppressors and enhancers of C9ORF72 DPR toxicity in human cells. We validated hits by performing secondary CRISPR–Cas9 screens in primary mouse neurons. We uncovered potent modifiers of DPR toxicity whose gene products function in nucleocytoplasmic transport, the endoplasmic reticulum (ER), proteasome, RNA-processing pathways, and chromatin modification. One modifier, TMX2, modulated the ER-stress signature elicited by C9ORF72 DPRs in neurons and improved survival of human induced motor neurons from patients with C9ORF72 ALS. Together, our results demonstrate the promise of CRISPR–Cas9 screens in defining mechanisms of neurodegenerative diseases.
“Cong guigen qingjie dao bentuhua: yi Xin Ma Panyu huiguan wei gean yanjiu, kan haiwai huaren shetuan yu Guangdong qiaoxiang guanxi de yanbian.” 从归根情结到本土化：以新马番禺为个案研究，看海外华人社团与广东侨乡关系的演变 (From Homecoming to China to Localisation: Case Studies of Singapore and Malaysian Panyu Associations) presented at ‘The International Conference on “The Development Trends of the Guangdong Overseas Chinese Organizations’ in Guangzhou, organized by Guangdong Returned Overseas Chinese Association and Guangdong Society of Overseas Chinese Studies, 9 December 2001.
Chongman yíwèn, wo xiàng fóluólidá zhou Clearwater zhensuo de zhuguan fasòngle yi feng diànzi yóujiàn, gai wangzhàn de Sheila céngjing xianshìguò wo de wangzhàn. Ta huídá shuo, zhensuo yu xila méiyou rènhé yèwù guanxì. Xianrán wo bèi piàn liao dàng wo miàn duì xila shí, ta shuo jìhuà you yigè zuìhòu yikè de biànhuà. Qíshí zhège chéngxù shì zài luo lì bei kaluóláinà dàxué yiyuàn wánchéng de. Rán'ér, zhè jia yiyuàn de wangzhàn méiyou liè chu shuluanguan jiéza de nìzhuan shì qí tígong de yiliáo fúwù zhi yi. Zài ji zhou zhihòu, yu xila de fènnù de diànzi yóujiàn jiaoliú zhihòu, wo xiangxìn xila yijing qi piànle wo.
Zhou, BH (2014) Chinese journalists’ social media usage and its influential factors: A survey on young journalists in Shanghai (Zhongguo xinwen congyezhe de shejiao meiti yunyong jiqi yingxiang yinsu: Yi xiang zhendui shanghai qingnian xinwen congyezhe de diaocha yanjiu). Journal of Journalism and Communication (Xinwen yu chuanbo yanjiu) 120(12): 34–53.
Focusing on the ‘top-down design’ of media convergence, market-oriented research relatively lacks in social solicitude and theoretical construction; valuing the ethics and obligations of converging media, the norm-oriented research demonstrates intense social solicitude but hardly receives industry-wide recognition. Both types of research fail to explain the full influence of media convergence. Considering that journalists are the critical actors of news production, the advancement of media convergence cannot proceed without the institutional arrangement from the top to the bottom as well as without the commitment and involvement of journalistic practitioners, particularly journalists, from the bottom to the top. The interaction between these two processes ultimately determines the scope, intensity and nature of the influences of media convergence.
(a) Visualization of the 3,000 sgRNA lentiviral library expressing mCherry in infected primary mouse neurons (grey = phase contrast, red = mCherry; live cells). (b, c) Validation of target protein reduction in Cas9+ primary neurons using sgRNAs targeting Xpo5 and Tmx2. Reduced abundance of target protein in primary neurons as measured by western blot was observed after more than 10 days of sgRNA expression (sgRNA transduction performed at DIV1). (d) Forest plots of all genes considered hits from each neuron screen with a non-zero effect estimate (95% C.I.) with estimated effect in center and error bars representing 95% credible interval of the effect estimate. Effect estimate is colored in blue if the gene was protective when knocked out and colored in red if it was sensitizing when knocked out.
Wo zài yù zhong èrshísì xiaoshí, ránhòu huòzhun baoshì. Lín dá cóng jiali zoule. Dang ta yitianhòu hé ta liánxì, ta shuo ta xiang huí dào shènglùyìsi. Wo de fángjian, zàixiàmiàn dì dìban shàng de rán mù lúzi jiarè, tài lengle, bùnéng zài nàliguò dongtian. Lín dá huí dàole yigè qián nán péngyou. Si hòu, ta ban dàole danfú, zuìhòu jiéhunle yigè wéi dàxíng zuzhi zuò diànnao gongzuò de báirén. Tamen xiànzài zhù zài la si wéi jia si, lín dá zài zhoulì dàxué danrèn jiàoxué zhíwù.
Treatment with the small-molecule PAR1 antagonist alone did not affect the survival of sporadic ALS iMNs (Supplemental Figure 6, K–P; 6 sporadic ALS patients), but the PAR1 antagonist blocked the ability of 3K3A-APC to rescue sporadic ALS iMN survival (Figure 5I and Supplemental Figure 6, Q–V; 6 sporadic ALS patients). Thus, 3K3A-APC can rescue C9ORF72 and sporadic ALS iMN survival through activation of PAR1.
Dì sì gè zhèyàng de biànhuà shì jiyú yi xìliè famíng, shoucì chuxiàn zài 19 shìjì zhongyè. Shèying shì dì yigè. Zhèli, jiqì jiang guang jùjiao zài tu fù you guangmin huàxué pin de ban shàng yi chansheng shìjué túxiàng. Zhè zhong jìshù bùtóng yú yiqián de, ta de chanpin shì yigè ganxìng de xíngxiàng, ér bùshì yi zu zì. Shiyòng diàn de jìshù suíhòu: Diànhuà, diànbào, liúshengji hé diànyingyuàn. Zài 20 shìjì, guangbò diànshì xíngshì de diànzi guangbò chuàngzàole zhichí yúlè shídài de dàzhòng chuánbò méiti.
The communication of technology is an important social activity, which has played a significant role in the area of language service industry. In order to help students get familiar with technical writing, the college of foreign languages and literatures of Fudan University has invited four technical writers from top 10 multinational companies to teach students how to write technical documents properly by citing examples and specific projects from the industry. Such professional training has proved to be a success since all students love the course and have more interest in translation industry. The rapid growth of service localization has resulted in inclusion of technical writing as a key component in a well-established professional’s translation competence.Therefore,it is necessary to incorporate technical writing courses into China’s translator-training system.
In light of the advanced international conception for e-learning translation instruction and the development of professional translation education in China, it is proposed that an e-learning platform conceived with knowledge systems be constructed. The new platform aims at utilizing advantages and characteristics of the online instruction, and at the same time categorizing instructive resources leading to knowledge service systems. This advantageous e-learning environment is featured with a collection of electronic resources of translation technology, instructive resources and interactive communication forums.
We next determined if 3K3A-APC’s ability to rescue autophagosome production, increase lysosomal numbers, lower levels of DPRs and mislocalized TDP-43, and lower glutamate receptor levels could rescue the degeneration of ALS iMNs. We first tested the ability of the iMN survival assay to replicate the neuroprotective effects previously shown for activated protein C in SOD1G93A mice (20). iMNs derived from an ALS patient carrying an SOD1A4V mutation degenerated significantly faster than control iMNs (Figure 5A and Supplemental Figure 5A; 3 controls and 1 SOD1A4V ALS patient) and 3K3A-APC rescued their survival (Figure 5A and Supplemental Figure 5A; 1 SOD1A4V ALS patient). Thus, the iMN model mimics disease biology observed in vivo.
In recent years, the Fujian press industry has stagnated due to frequent turnover of personnel. Given that the number of practicing journalists in this province is difficult to determine, the authors adopted the snowball sampling method by firstly contacting the persons-in-charge of the newsroom and requesting them thereafter to recruit journalists to answer the survey. Considering the particularity of the respondents’ profession, that is, having flexible working hours, two assistants were assigned to distribute the printed questionnaires before and after the plenary press conference or the newsroom convention from July to August 2015.
Zuìjìn yóu Xiàwēiyí Dàxué Chūbǎnshè chūbǎn de “ABC Hàn-Yīng Yànyǔ Cídiǎn” bāohán le yuē 4000 duō tiáo Hànyǔ yànyǔ, gēnjù Hànyǔ Pīnyīn zhuǎnlù hé Hànzì (biāozhǔn jiǎntǐ), ànzhào yànyǔ shǒu cí de zìmǔ shùnxù páiliè, fùdài de Yīngwén shūmiàn zhíyì (rú bìyào yě huì cǎiyòng yìyì). Qítā nèiróng bāohán: jiǎnyào yòngfǎ zhùshì, láiyuán, bìngxíng biǎodá, cānzhào yǐnyòng yǐjí yìngyòng shílì. Yànyǔ shì yóu yī ge guānjiàncí (Zhōng-Yīngwén) suǒyǐn zēngbǔ de, tǐxiàn zài suǒyǒu shèjí de cítiáo hé huàtí li. Biānzhě duì zhèxiē yànyǔ zài chuántǒng yǔ dāngdài Zhōngguó li de dìngyì, jiégòu, yòngtú hé lìshǐ jìnxíng le xuéshù jièshào, lièchū le wénxiàn jí hé xiāngguān yànyǔ de xuéshù yánjiū.
Dang fángwu fatíng cáipàn jìnrù fángjian shí, a shén lì jùjué zhànlì shí kenéng fànle cuòwù. Cáipàn jieshì shuo, bùshì wèile gèrén ér shì zunzhòng fatíng. Ta jíshí fourèn ta méiyou qianshu de zuyue bù yunxu wo shouqu zujin. Cáipàn shuo, rúguo a shén lì zài dì èr tian ba 1,269.50 Meiyuán (baokuò fayuàn fèiyòng) jiao geile tuoguan rén, ta jiang yunxu tíchu wéixiu wèntí. a shén lì shuo ta huì you qián de. Dang fatíng dì èr tian zaoshang chóngxin zhàohuí shí, ta méiyou. Fángwu fayuàn cáipàn yuán qianshule yigè mìnglìng, gei ta yigè xingqí tongguò rènzhèng zhipiào huò xiànjin zhifù wo de qián. Rúguo méiyou zhifù zhè bi qián,“pànjué hé quzhú lìng” jiang bèi mòrèn fachu.“
Zài qízhong yigè changhé, wo gàosù xila, wo shì tú zhaodào yigè méiyou jiéhun de nurén, yào hé wo yiqi shenghuó. Ta de guanzi bèi shùfù hòu, ta wúlì. Rán'ér, dang women jiéhun de shíhòu, women yijing jiandan dì wéi ta zuòle yigè shoushù lái niuzhuan shuluanguan jiéza. Zì nà yilái, zhè xiàng jìshù jìnbùle. Xila zài hùliánwang shàng jìnxíng sousuo, zài fóluólidá zhou de kèlì er wò tè zhaodàole yigè dìfang, jiang yi 10,000 meiyuán jìnxíng nìzhuan chéngxù. Ta rènwéi, boshìdùn kexué gongsi de jiànkang baoxian kenéng huì zhifù bùfèn chéngben. Rúguo you xìngqù, wo jiang bùdé bù zhifù qíyú fèiyòng.