Jintian de rénmen yìshí dào yidài rén de chajù, zhè bùshì 1960 niándài pànnì qingnián de chajù, ér shì yu wénhuà jìshù youguan de chajù. Suirán lao yi bèi zhuanzhù yú shu de xuéxí, tamen de háizimen liúxíng wénhuà. Niánqing rén zài wán shìpín yóuxì fangmiàn biaoxiàn chu jí dà de jìqiao. Tamen de yinyuè lùyin, diànshì hé diànying rénwù de zhishì shì zhen bàng. Youxie rén yijing ba tamen de nénglì yu jìsuànji yiqi gongzuò zài yi jìshù wéi zhongxin de yèwù de qiányán. Jiù de pao chu tamen de shou, bìng àonao “wénmíng” de shuailuò, yinwèi dú xie nénglì sìhu yijing shòuku. Zhè kenéng bùshì wénmíng benshen de shuailuò, ér shì yigè wénmíng tìdài lìng yigè wénmíng.
Shì 4 yuè 5 rì xingqí yi wanshàng. Wo wèi Julianne xiele yi fèn shengmíng, yaoqiú Walgreen xingqíwu gei wo zhipiào. Rán'ér, wo de zhuyào mùdì shì yào you lìng yigè jihuì yu zhulì'an yiqi. Ta dabaole dàizi qù mìxixibi zhou, dài shàng yi jiàn jiafa hé yi ba gaodà de youqù de màozi, bìng pá shàng wo de che, kaiche dào wò er gélín. Zhulì'an shuo, ta de gonggòng qìche zài shàngwu 6 dian zuoyòu líkaile shèngbaoluó mìxixibi zhou, ta bìxu gan shàng yi liàng qingchén de chéngshì bashì dào hui gou chezhàn.
Dang nurén cóng wo nàli ná qián de shíhòu, wo hen danxin wo bèi piànle. Wo shì yigè yúchun de laorén jiyu tóngyì. Nàgè nurén ba wo dàng zuò shì lìng yiduan dì shouduàn. Rán'ér, yu zhulì'an yiqi, wo ye rènwéi wo yuànyì gei ta qián - bùshì tài duo, ér shì yixie - shì wo guanxin de yigè jixiàng. Nánrén dì xìngbié jiang shì yigè jixiàng, fùnu yi zhèngquè de fangshì guanxin tamen. Fùnu de qián jiang shì yigè jixiàng, shuomíng zhège rén huì wèi ta zouchu lù. Suoyi women mei gèrén dou bìxu jiyu yidiandian ràng duìfang chéngzhang.
Dì sì gè zhèyàng de biànhuà shì jiyú yi xìliè famíng, shoucì chuxiàn zài 19 shìjì zhongyè. Shèying shì dì yigè. Zhèli, jiqì jiang guang jùjiao zài tu fù you guangmin huàxué pin de ban shàng yi chansheng shìjué túxiàng. Zhè zhong jìshù bùtóng yú yiqián de, ta de chanpin shì yigè ganxìng de xíngxiàng, ér bùshì yi zu zì. Shiyòng diàn de jìshù suíhòu: Diànhuà, diànbào, liúshengji hé diànyingyuàn. Zài 20 shìjì, guangbò diànshì xíngshì de diànzi guangbò chuàngzàole zhichí yúlè shídài de dàzhòng chuánbò méiti.
Wo zài 1979 nián 10 yuè zài meiguó húlu zhong shiqùle gongzuò. Wo de qi zi yiwéi wo méiyou nulì, yexu shì zhen de. (Bùguò,70 niándài mò yóujià xiàdié shí, gongsi yòng yú jiànzào lí àn shíyóu zuànji de dàxíng qizhòngji de xiaoshòu liàng dàfú xiàhuá. Ta shuo, shiyè rényuán shì “zuìdi dian”. Zài 1980 nián 9 yuè de yigè zhenglùn zhihòu, ta da diànhuà gei jingchá, shuo ta méiyou anquán gan. Tamen diàochá, dàn méiyou li yóu dàibu wo.
Dec. 2019: Our paper ‘‘Link Prediction Under Imperfect Detection: Collaborative Filtering for Ecological Networks’’ has been accepted by IEEE Transactions on Knowledge and Data Engineering! This paper is co-authored by Xiao, Eugene Seo, Justin Clarke, and Rebecca Hutchinson, all from EECS at Oregon State! Justin was with us as an undergraduate student by the time of submission, and he is now at UMass for his graduate degree. Congratulations, team!
Zhèli de jiashè shì, tongxìn móshì jiang qí benzhí de dongxi fùyu biaodá shì de nèiróng. Huàn jù huàshuo, suo shuo dehuà shòudào ta de shuofa de yingxiang. Rúguo zhè shì zhen de, nàme bùtóng lèixíng de gonggòng tiyàn jiang gensuí tongxìn jìshù de biànhuà. Xiezuò de wénhuà jiang bùtóng yú zaoxian de koutóu wénhuà. Yìnshua wénxué de wénhuà jiang bùtóng yú shougao wénhuà.
(A) Production of Hb9::RFP+ iMNs and survival tracking by time-lapse microscopy. (B and C) Survival of control (CTRL) and C9ORF72 ALS patient (C9-ALS) iMNs with a 12-hour pulse treatment of excess glutamate shown for each individual line separately (B), or for iMNs from all lines in aggregate (C). For B and C, n = 90 iMNs per line for 3 control and 2 C9-ALS lines, iMNs quantified from 3 biologically independent iMN conversions per line. (D) Survival of control and C9ORF72 ALS patient iMNs after withdrawal of neurotrophic factor supplementation. iMNs from all control or C9ORF72 patient lines shown in aggregate. n = 90 iMNs per line for 3 control and 3 C9-ALS lines, iMNs quantified from 3 biologically independent iMN conversions per line. (E and F) Survival of control and sporadic ALS (sALS) patient lines after glutamate treatment (E) or withdrawal of neurotrophic factor supplementation (F). iMNs from all control or C9ORF72 patient lines shown in aggregate. n = 90 iMNs per line for 3 control and 6 (E) or 5 (F) sporadic ALS lines, except sALS6 which had 60 (E) or 40 (F) iMNs counted. iMNs quantified from 3 biologically independent iMN conversions per line. (G–I) Immunofluorescence analysis of total TDP-43 (G) and quantification of the ratio of nuclear to cytoplasmic TDP-43 in control, C9-ALS (H), or sporadic ALS (I) iMNs. Ratio of nuclear to cytoplasmic TDP-43 in individual iMNs treated with 10 nM inactive 3K3A-APC or 3K3A-APC for 6 days. iMNs from 2 controls and 2 C9-ALS patients (H) or 4 sporadic ALS patients (I) were quantified. n = 30 (controls), 30 (C9-ALS), or 36 (sporadic) iMNs per line per condition from 2 biologically independent iMN conversions of 2 control, 2 C9-ALS, or 4 sporadic ALS lines were quantified. Each gray circle represents a single iMN. Median ± interquartile range. Unpaired Mann-Whitney test. Scale bars: 5 μm. Dotted lines outline the nucleus and cell body. For iMN survival experiments, significance was measure by 2-sided log-rank test using the entire survival time course. The day of differentiation stated on each panel indicates the day of differentiation on which the experimental treatment or time course was initiated.
Say (there is) a fire disaster, which is often reported as an explosion. We often rush to fire disasters, chatting and interviewing with firemen on the site, (to know) there are lots of detonations in fire disasters. Even if not all detonations correspond to explosion, people who have not experienced the scene would likely label the sound ‘Bang’ as explosion before recording in Weibo the ‘explosion’ of fire somewhere… (Journalists) have discrimination, which is something lacked by ordinaries. (Interviewee No. 2)
For Western journalism researchers, media convergence generally refers to the ‘cooperation and collaboration between formerly distinct media newsrooms and other parts of the modern media company’ (Deuze, 2004: 140). Chinese scholars were considerably inclined to use the phrase ‘full-media’ (Quan Meiti) to describe the convergence process. Full-media, which is a term coined by Chinese media practitioners, implies a figure of oriental holism under the perspective of Chinese traditional philosophy (Ji et al., 2013). Mai (2012: 41) employed observation and in-depth interviews and defined full-media convergence as ‘a mode of structural integration of news production, dissemination and business operation on the platforms of new communication technology’.

We thank E. Crane and B. Li for help with RNA-seq and helpful discussions; K. Han for helpful discussions and image analysis; and the Stanford Neuroscience Microscopy Service, supported by NIH NS069375. This work was supported by NIH grants R35NS097263 (A.D.G.), DP2HD084069 (M.C.B.), and R01NS097850 (J.K.I.), a National Science Foundation Graduate Research Fellowship (N.J.K.), a National Human Genome Research Institute Training Grant (M.S.H.), the Robert Packard Center for ALS Research at Johns Hopkins (A.D.G.), Target ALS (M.C.B. and A.D.G.), the Stanford Brain Rejuvenation Project of the Stanford Neurosciences Institute (M.C.B. and A.D.G.), the Muscular Dystrophy Association (J.K.I.), and Department of Defense grant W81XWH-15-1-0187 (J.K.I.). J.K.I. is supported as a New York Stem Cell Foundation–Robertson Investigator.
A third conclusion from our findings is that a single therapeutic approach can rescue both gain- and loss-of-function C9ORF72 disease processes. 3K3A-APC treatment reduces levels of NMDA receptors on iMNs and hippocampal neurons in vivo and rescues NMDA-induced excitotoxicity in C9orf72-deficient mice. Our observation that 3K3A-APC stimulates autophagosome formation indicates that 3K3A-APC can also rescue this aspect of the loss of C9ORF72 function. 3K3A-APC significantly lowers DPR levels in C9ORF72 ALS iMNs and C9ORF72 BAC transgenic mice, thereby mitigating this gain-of-function disease process.
Treatment with the small-molecule PAR1 antagonist alone did not affect the survival of sporadic ALS iMNs (Supplemental Figure 6, K–P; 6 sporadic ALS patients), but the PAR1 antagonist blocked the ability of 3K3A-APC to rescue sporadic ALS iMN survival (Figure 5I and Supplemental Figure 6, Q–V; 6 sporadic ALS patients). Thus, 3K3A-APC can rescue C9ORF72 and sporadic ALS iMN survival through activation of PAR1.

16 Expertise is defined as a source's “presumed knowledge and ability to provide accurate information.” See Petty, R. and Wegener, D., Attitude Change: Multiple Roles for Attitude Change (Boston: McGraw-Hill, 1998), p. 344. Objectivity refers to perceptions of media sources to be unbiased, accurate, fair and “to tell the whole story.” See Iyengar, S. and Kinder, D.R., Psychological Accounts of Agenda-Setting (Beverly Hills: Sage, 1985); Miller, J. and Krosnick, J., “News media impact on the ingredients of presidential evaluations: politically knowledgeable citizens are guided by a trusted source,” American Journal of Political Science, Vol. 44, No. 2 (2000), pp. 301–15.
Dàgài zài zhège shíhòu, xila hé wo you wú baohù dì xìng xíngwéi, dàgài zài 3 yuè zhongxún huòzhe wanqí. Women dangshí dou méiyou tài duo xiangfa. Wo bù rènwéi xila huì huáiyùn, yinwèi wo bù xiangxìn ta you shoushù lái niuzhuan shuluanguan jiéza. Xila shuo ta ye rènwéi, yinwèi ta de niánlíng, ta bù huì huáiyùn. Xìng shì women zuì hao de yibùfèn, dànshì, women rènwéi zhè shì quánbù.
Because autophagy induction can enhance TDP-43 turnover in motor neurons (26), we wondered whether 3K3A-APC treatment could prevent the cytoplasmic accumulation of TDP-43 in ALS iMNs. 3K3A-APC treatment for 6 days significantly increased the nuclear-to-cytoplasmic ratio of TDP-43 in C9ORF72 and sporadic ALS iMNs to control levels (Figure 3, G–J; 2 controls, 2 C9ORF72 ALS, and 6 sporadic ALS patients). Thus, 3K3A-APC treatment can rescue autophagosome formation, lower DPR levels in C9ORF72 ALS iMNs and rescue DPR-mediated neurotoxicity, and reverse the cytosolic accumulation of TDP-43 in C9ORF72 and sporadic ALS patient iMNs.
For Western journalism researchers, media convergence generally refers to the ‘cooperation and collaboration between formerly distinct media newsrooms and other parts of the modern media company’ (Deuze, 2004: 140). Chinese scholars were considerably inclined to use the phrase ‘full-media’ (Quan Meiti) to describe the convergence process. Full-media, which is a term coined by Chinese media practitioners, implies a figure of oriental holism under the perspective of Chinese traditional philosophy (Ji et al., 2013). Mai (2012: 41) employed observation and in-depth interviews and defined full-media convergence as ‘a mode of structural integration of news production, dissemination and business operation on the platforms of new communication technology’.
Wo ba wo de xin qizi hé nu'ér dài dào binxifaníya zhou de mi'er fú dé, wo cóng fùmu jìchéngle yi suo fángzi. Xi lì yà huì qù nàli de gaozhong háishì zài míng ní abo lì si? Lián shuo ta xihuan zhù zài yigè chéngshì. Zài mi'er fú dé liang tianhòu, women kaiche zhí ben míngnísudá, kaishi xin de shenghuó. Xi lì yà bèi pìn wéi míngnísudá zhou beibù de pàtèlikè·henglì gaozhong de zishen rénshì. Ta zài yingguó niújin fùjìn de guójì xuéxiào dùguòle yi nián de shíjian, jiangle chusè de yingyu. Lián zhunbèi xin shenghuó qu, shìyìng meiguó shenghuó, méiyou lìjí jìhuà. Yóuyú canyùle yèzhu xiaozu, wo jianduan de shì míng ní abo lì si shì shì zhang de hòuxuan rén. Wo de xin jiatíng bèi jièshào gei lóuzhu péngyou.
×