Jan. 2019, Check out the new paper: ‘‘Learning Nonlinear Mixtures: Identifiability and Algorithm’’. In this work we push forward parameter identifiability of linear mixture models (LMM) to nonlinear ones. LMM finds many applications in blind source separation-related problems, e.g., hyperspectral unmixing and topic mining. In practice, however, the mixing process is hardly linear. This work studies a fundamental question: if there is nonlinearity imposed upon an LMM, can we still identify the underlying parameters of interest? The interesting observation of our work is that: under some conditions, nonlinearity can be effectively removed and the problem will boil down to an LMM identification problem — for which we have tons of tools to handle.
(A) Survival of iMNs from 3 control or 1 SOD1A4V ALS patient line in excess glutamate with 10 nM inactive 3K3A-APC or 3K3A-APC. n = 90 iMNs per line per condition, iMNs from all control lines shown in aggregate for clarity. iMNs quantified from 3 biologically independent iMN conversions per line. (B) Survival of iMNs from 2 C9-ALS lines in excess glutamate with inactive 3K3A-APC or different concentrations of 3K3A-APC. n = 90 iMNs per line per condition, iMNs from both lines shown in aggregate for clarity. iMNs quantified from 3 biologically independent iMN conversions per line. (C) C9-ALS iMNs on day 12 of survival in excess glutamate with inactive 3K3A-APC or 3K3A-APC treatment. This experiment was repeated 3 times with similar results. Scale bar: 100 μm. (D) Survival of control iMNs in excess glutamate with 10 nM inactive 3K3A-APC or 3K3A-APC, n = 90 iMNs per line per condition for 3 control and 3 C9-ALS lines, iMNs quantified from 3 biologically independent iMN conversions per line. (E–G) Survival of iMNs from 2 C9-ALS lines in excess glutamate with 3K3A-APC with or without 3 μM PAR1 antagonist treatment (E) or PAR2 antagonist treatment (F). n = 90 iMNs per line per condition, iMNs from both lines shown in aggregate for clarity. iMNs quantified from 3 biologically independent iMN conversions per line. Survival of iMNs from 2 C9-ALS lines in excess glutamate with 3K3A-APC with or without 9 μM PAR1 ASO treatment (G). n = 90 iMNs per line per condition, iMNs from both lines shown in aggregate for clarity. iMNs quantified from 3 biologically independent iMN conversions per line. Each trace includes neurons from 2 donors with the specified genotype. All iMN survival experiments were analyzed by 2-sided log-rank test and corrected for multiple comparisons if applicable. Statistical significance was calculated using the entire survival time course. (H and I) Survival of iMNs from sporadic ALS (sALS) clone 1 in excess glutamate with 10 nM inactive 3K3A-APC or 3K3A-APC (H), or with 3K3A-APC and DMSO or a PAR1 antagonist (I). n = 90 iMNs per condition. iMNs quantified from 3 biologically independent iMN conversions. For all iMN survival experiments, significance was measure by 2-sided log-rank test using the entire survival time course. The day of differentiation stated on each panel indicates the day of differentiation on which the experimental treatment or time course was initiated.
To determine if the effects of 3K3A-APC on stimulating autophagy in C9ORF72 and sporadic ALS iMNs were sufficient to lower DPR and cytoplasmic TDP-43 levels, we first measured levels of glycine-arginine [poly(GR)] and proline-arginine [poly(PR)] DPRs in C9ORF72 ALS iMNs with and without 3K3A-APC treatment. Treatment with 3K3A-APC for 6 days reduced the number of nuclear poly(GR)+ and poly(PR)+ punctae in C9ORF72 ALS iMNs to control levels (Figure 3, A–C, and Supplemental Figure 3, A–E; 2 controls and 2 C9ORF72 ALS patients). Dot blot analysis for poly(GR) confirmed the decrease in iMNs after 3K3A-APC treatment (Figure 3, D and E). Moreover, 3K3A-APC reduced total nuclear and cytoplasmic levels of poly(GR)+ and poly(PR)+ punctae in C9ORF72 ALS iMNs (Supplemental Figure 3, F–H and J–L) and did not significantly alter the ratio of nuclear to cytoplasmic poly(PR)+ punctae, although it slightly lowered the ratio of nuclear to cytoplasmic poly(GR)+ punctae intensity (Supplemental Figure 3, I and M). These data indicate that 3K3A-APC treatment decreased both nuclear and cytoplasmic levels of DPRs. qRT-PCR using primers specific for C9ORF72 variants 1 and 3 (Supplemental Table 3) showed that 3K3A-APC did not reduce RNA levels of the repeat expansion (Supplemental Figure 3N), excluding the possibility that the reduced DPR levels were caused by transcriptional repression. 3K3A-APC also did not alter the expression of genes associated with the integrated stress response (Supplemental Figure 3O), indicating that its ability to lower DPR levels was independent of this pathway.
Analysis was performed with the statistical software package Prism Origin (GraphPad Software). Statistical analysis of iMN survival experiments was performed using a 2-sided log-rank test to account for events that did not occur (i.e., iMNs that did not degenerate before the end of the experiment). For each line, the survival data from 90 iMNs were selected randomly using Microsoft Excel, and these data were used to generate the survival curve. If all iMNs degenerated in a given experiment, statistical significance was calculated using a 2-tailed Student’s t test.
Shangjia kenéng yijing dì yi cì shiyòng ta. Tamen zài fangwèn mòsheng hé yáoyuan dì dìfang de jinglì cìjile yuyán, zongjiào, xísú hé sixiang zhi jian de bijiào. Zhège duan shouxie de jiaoben chuàngzàole yi zhong gèngjia jinglì chongpèi hé tànsuo de shèhuì lèixíng. Yixie xúnwèn zhe shì fazhan zìji de sixiang xìtong de zhéxué jia. Suízhe xiezuò zhishì guangfàn chuánbò, qí shìjué biaojì chéngwéi hàoqí xin de duìxiàng, yóuqí shì zài jùyou qiángliè koutóu chuántong de shèhuì. Zhè zhong shèhuì cúnzài yú 5 shìjìde xilà chéngbang. Hé ma shi, jì dé bù dú, shì xilà rén liánhé de wénhuà juzhèn. Rán'ér, xiàng Hesiod,Aeschylus hé Sophocles zhèyàng de zuòjia ye zài xiànchang.
“Chongzu quanli yu huangui xingshi: Nanda 1964 zhi 1968 nian de gaizhi yu gaige”  重组权力与换轨行驶:南大1964至1964年的改制与改革  (Reconfiguring Power and Changing Track: The Changes and Transformation of Nanyang University, 1964-1968), presented at Nantah History Workship on “Zuqun, jiaoyu, guojia: 1953 zhi 1980 nian de Nanyang Daxue”  族群、教育、国家:1953至1980年的南洋大学 (Ethnicity, Education, and Country: Nanyang University, 1953-1980), in Singapore organized by the Centre for Chinese Language & Culture, Nanyang Technological University, 5 August 2006.
“Zhuandong luopan: Chen Jiageng he Li Guangqian de huaren lisan jingyan” 转动罗盘:陈嘉庚和李光前的华人离散经验  (Turning Compass: Diasporic Chinese Experience of Tan Kah Kee and Lee Kong Chian), presented at International Conference on “Tan Kah Kee and Lee Kong Chian: Their Significance in the Making of Modern Singapore and Malaysia,” in Singapore, organized by the National Library Board and the Tan Kah Kee Foundation, 28-29 November 2008.
Hao xiaoxi shì, ta xiànzài zài fùguó yínháng youyi fèn gongzuò, yigè mei xiaoshí zhifù 15 meiyuán. Ta cóng wo nàli toule qián lái zhifù yínháng fèiyòng. Ta ye zhèngzài jìnrù wojia de lóu xià danwèi, bìng you jinjí yuánzhù zhifù yigè yuè de zujin hé sunhui yajin. Wo zuò chule yigè juédìng. Wo keyi xiàng meiguó yínháng bàogào qizhà xíngwéi bìng shouhuí zijin, ye kenéng jiang xila sòng dào jianyù, fouzé wo keyi jieshòu dàoqiè, xiwàng yiqiè shùnlì. Wo xuanzéle hòu zhe.

Shumiàn yuyán cóng shangyè kaishi. Gudài su mei er de shangrén xuyào yi zhong fangfa lái genzong shangyè jiaoyì. Rúguo shangrén chúcún guwù, ta xuyào zhidào zài tèdìng wèizhì baocún mei zhong lèixíng guwù de duoshao. Lìshi xué jia rènwéi, su mei er shangrén shiyòng yóu kao niántu zhì chéng de dài bì lái xiàngzheng dàliàng de shangpin. Yi zhong xíngzhuàng kenéng yìwèizhe liù púshì'er xiaomài; lìng yigè, yi púshì'er xiaomài; hái youyi jialún ganlan yóu. Tongguò jiang zhèyàng de biaojì fàngzhì zài wan xíng niántu róngqì zhong bìngqie xiangyìng dì biaojì wàibù, shangjia jiang zhidào tasuo yongyou de mei zhong shangpin de duoshao hé duoshao. Dàng shangrén yìshí dào wan limiàn de niántu biaojì suo dàibiao de xiangtóng xìnxi yóu wàimiàn de biaojì biaodá shí, zhèngquè de xiezuò kaishi. Yinci, tamen keyi mian qù wan hé yi píngban diànnao shàng míngwén de xíngshì tígong xìnxi.
Conflict of interest: JKI is a co-founder of AcuraStem Incorporated. JKI declares that he is bound by confidentiality agreements that prevent him from disclosing details of his financial interests in this work. BVZ is a scientific founder and chairs the scientific advisory board of ZZ Biotech LLC, a biotechnology company with a mission to develop activated protein C and its functional mutants for the treatment of stroke and other neurological disorders.
“Lisan zhong de ningju: Panyu huiguan gongneng de fahui yu juxian” 离散中的凝聚:番禺会馆功能的发挥与局限 (Cohesion within the Dispersion: The Functionality of Panyu Associations), presented at the “Maritime Asia and the Chinese Overseas, 1405-2005,” The Third International Conference of Institutes & Libraries for Chinese Overseas Studies, in Singapore, organized by Inter-Agency Committee on the Chinese Overseas Databank & Research, Singapore, and Ohio University Libraries, Athens, in association with International Zheng He Society, Singapore, 18-20 August 2005.
Jan. 2019: Check out this new submission: ‘‘Block-Randomized Stochastic Proximal Gradient for Low-Rank Tensor Factorization’’. This work uses a combination of randomized block coordinate descent and stochastic proximal gradient to decompose large and dense tensors with constraints and regularizations. The complexity saving is quite surprising. The total number of MTTKRPs (which dominates the CPD complexity) needed for the proposed algorithm is very small (see BrasCPD and AdaCPD in the figure).
Wo ba zhè feng xìn dài huíle lián. Ta quèxìn zhè shì yigè jia de. Bìjìng, wo méiyou kàn dào yi míng zhensuo de gongzuò rényuán gei xila xie xìn. Ta keyi zìji zài diànnao shàng xie xìn, jìnrù dàlóu, ba ta cóng koudài li ná chulái, ránhòu yòng zìji bianxie de xìnjiàn zàicì chulái. Wo bùdé bù chéngrèn zhè zhong qíngkuàng shì kenéng de. Xila céngjing wèizàoguò wénjiàn.
Such standpoint has led local press groups to successively adopt diverse approaches over the past two years to cope with the challenge of new media. Among these approaches, the ‘extendedly ameliorated’ path, namely the implementation of incremental development of newspapers through flow reconstruction whilst retaining their original production system (Mai, 2012: 118), has become a common option of most local press groups. Although media convergence exerts an increasingly significant effect on these local press groups, relevant empirical studies remain limited at present. The current study analyses the perceptions of local newspaper journalists on and evaluations of media convergence through a survey and 20 in-depth interviews so as to disclose the effects of the dominant path of media convergence on local press groups based on the understanding of and reflection on the viewpoints of the ‘insiders’.

5 See, for example, Li, C.-c., Voices of China: The Interplay of Politics and Journalism (New York: Guilford Press, 1990); Lynch, D.C., After the Propaganda State: Media, Politics, and “Thought Work” in Reformed China (Stanford: Stanford University Press, 1999); Esarey, A., “Cornering the market: state strategies for controlling China's commercial media,” Asian Perspective, Vol. 29, No. 4 (2005), pp. 37–83; Zhao, Y., Communication in China: Political Economy, Power, and Conflict (Lanham: Rowman & Littlefield, 2008); Polumbaum, J. and Lei, X., China Ink: The Changing Face of Chinese Journalism (Lanham: Rowman & Littlefield, 2008).
The lack of models for sporadic ALS has hampered efforts to identify disease mechanisms and therapeutic targets that apply broadly to multiple sporadic forms of ALS (3, 7). To address this, we derived induced pluripotent stem cells (iPSCs) from a cohort of sporadic ALS patients and generated induced motor neurons (iMNs) from these iPSCs. We show that similarly to C9ORF72 ALS iMNs, the sporadic ALS iMNs from all 6 donors degenerate significantly faster than controls and show pronounced mislocalization of transactive response DNA-binding protein 43 kDa (TDP-43). Thus, these sporadic ALS iMNs display relevant disease processes.
Interestingly, in the presence of 50 nM bafilomycin, sporadic ALS iMNs also contained significantly fewer GFP+mRFP+ vesicles than controls (Figure 2, A and C, and Supplemental Figure 2B; 3 controls and 5 sporadic ALS patients), indicating that autophagosome formation was impaired in sporadic ALS iMNs. Thus, both the C9ORF72 and sporadic ALS iMNs display decreased rates of autophagosome formation.
Studies in patients and animal and cell models have linked neuronal hyperexcitability to ALS (6, 27–32), but it remains unclear if there are common cell-autonomous mechanisms that drive hyperexcitability in different ALS patients. We previously found that reduced C9ORF72 levels lead to elevated surface-bound levels of glutamate receptors in C9ORF72 ALS iMNs, C9ORF72-deficient mice, and C9ORF72 patients, and that these differences were not caused by differential gene expression (4). We also showed that the elevated glutamate receptor levels increased sensitivity to glutamate-induced excitotoxicity in vitro and in vivo (4).
Ránhòu lìng yi tào jìshù chuxiànle. Tongguò shèying, xiàoxiànghuà jia zài huàbù shàng baochí miànbù túxiàng de youyòng xìng xùnsù bianzhí. Jiqì nénggòu chansheng bi zuìgao jìshù de yìshùjia gèng hao de duìxiàng de xiàoxiàng. Dang liúshengji hé diànying zhàopiàn chuxiàn shí, guanzhòng bàolù zài geshou huò yanyuán de lian hé shengyin de gè rén sùzhì. Bùjiu yiqián, wénhuà zhùyì lì cóng yigè xìjù jù zuòjia de zuòqu jia huò zuòjia suo xie de wénzì zhuanyí dào yanzòu zhe rúhé jieshì huò chéngxiàn zhèyàng de zuòpin. Zhiyou shaoshù chúncuì zhuyì zhe zhidào huò guanxin bianjù zài diànying zhong de zuòpin huò zuòqu jia zài chuàngzuò yinyuè fangmiàn de zuòyòng, shi yixie liúxíng geshou chéngwéi míngxing.
Lín dá líkai gai dìqu hòu, wo yùjiànle an, yigè báirén nu, céngjing gen wo de péngyou hé fángdong ha wéi. Ha wéi de qián shìyou ken·kèlisidì ansen (Ken Christianson) yijing kaishile yigè míng wèi “dí huìjiàn rén” de zìyóu liútong bàozhi, wèi you xìngqù huìjiàn qíta danda di danshen rénshì. Zhèyàng jiù hé ha wéi liánxìle. Ta huàn you yìyù zhèng. Ta dí gege yijing shìtú ba ta zhì yú jingshénbìng yuàn, dàn ta yijing táotuole. Zhè shì yigè you xiyin lì de gùshì. Wo chéngle an dì péngyou, hen kuài ta de liànrén hé wèihunfu. Yijiubaliù nián xiàtian, wo dài ta qù dong jie wojia.

It is said that even in his lifetime a few of Wang’s characters or his signature were priceless. Down through the ages, aspiring students of that most basic yet highest art in China, calligraphy, have copied and preserved traces of his style. The most famous example of his writing is the Lantingxu (“Preface to the Poems Composed at the Orchid Pavilion”), which recorded a famous gathering of some 42 literary figures during the Spring Purification Festival of 353 ce to compose poems and enjoy the companionship of wine. Wang’s work was written in the xingshu, or “running script,” and has become the model for that particular style of writing. Among other generations of calligraphers in the family, Wang Xianzhi (344–386 ce), the youngest son of Wang Xizhi, was the most famous.
Liánrì qi yuè wu rì cóng beijing fanhuí míngnísudá zhou. Women liang rén yú qi yuè èrshí rì (xingqí'èr) fei wang xiyatú, zài huáshèngdùn bèi lái wéi shìchá ta de péngyou lú nushì. Jingguò 3 tian de fangwèn, women huíláile. Bùjiu zhihòu, lián fei dào tiánnàxi zhou nà shí wéi'er, bàifangle ta de mèimei wèi gé hé en gé de zhàngfu chá kè·pà er. Wo zài qi yuè sanshíyi hào fei wang huáshèngdùn gelúnbiya tèqu, huìjiànle cóng nà shí wéi'er jiàshi de lián héwén qí. Women yiqi kai che qù mi'er fú dé. Ránhòu san tian, women canguanle fèichéng, niuyue shì hé niu hei wén kangnièdígé zhou. Liánxì hen shengqì. Ta ba yuèchuhuí dào beijing. Dangrán, wo baochí xila de huáiyùn shì yigè mìmì.
61 After 9 April those Beijingers with the most negative views of Japan avoided newspapers. See D. Stockmann, “What kind of information does the public demand? Getting the news during the 2005 anti-Japanese protests,” in S. Shirk (ed.), Changing Media, Changing China, forthcoming. Since non-readers were excluded from the statistical analysis, avoidance did not influence the empirical results presented here.
Wénlín CDL JavaScript shǐyòng Wénlín Zìxíng Miáoshù Yǔyán (CDL) kāifā: CDL shì yī ge XML yìngyòng chéngxù, yī ge jīyú biāozhǔn de zìtǐ hé biānmǎ jìshù, yòngyú jīngquè, jǐncòu de miáoshù, xiǎnshì hé suǒyǐn suǒyǒu Hàn zìfú (Zhōng-Rì-Hán-Yuè=CJKV), bāokuò biānmǎ hé fēi biānmǎ zìfú. Wénlín CDL jìshù dǎpòle 64k zìxíng de zhàng'ài, bù chāoguò 1.4 zhàozìjié biànkě huòdé quántào Unicode 7 CJK zhīchí, tóngshí yěshì nèi zhìyú zìtǐ de jiějué fāng'àn, dúlìyú shǒuxiě shíbié. Wénlín CDL shì yī xiàng gémìngxìng de héxīn jīchǔ jiégòu jìshù, wèi shùjù jiégòu, shùjù cúnchǔ hé shùjù jiāohuàn tígōngle jiānrúpánshí de kuàngjià. Wenlin CDL jìshù kě wúxiàn kuòzhāng Unicode jí, nénggòu bǐ qítā jìshù gèng kuài, gèng zhǔnquè de dú qǔ, shūxiě bìng shíbié CJKV zìtǐ. Tā jiāng chéngwéi CJKV zìtǐ shūrù, suǒyǐn, shíbié hé shūchū de diǎnfàn. Wénlín CDL duì CJKV xùliè jìnxíng páixù. Yù liǎojiě Wénlín CDL jìshù de gèngduō xiángqíng, qǐng diǎnjī cǐchù.
Our data indicate that motor neurons derived from C9ORF72 and at least a subset of sporadic ALS patients share similar defects in autophagosome formation and glutamate receptor accumulation. Importantly, PAR1 activation by 3K3A-APC can reverse these C9ORF72 and sporadic ALS disease processes in vitro and in vivo (Figure 7). We draw several key conclusions from our findings.

Another explanation for journalists’ disinclination to provide news to the new media centre is the emerging conflict between the traditional and new media departments of the Fujian press industry. The main purpose of media convergence is to reconstruct the news production workflow and manifest the notion of ‘collection once, generation into varieties and dissemination in diversities’. Under the dominant path, the original departments of new media outlets are incorporated into the department of new media centre. From the perspective of newspaper office leadership, the timeliness of newspapers falls short of new media; thus, the latter is likely to further decrease the market of the former by intensifying the decline in newspaper readers. The leadership in Fujian’s press groups has been exploring various methods of press release, such as supplying basic facts to new media whilst providing details, background information and other in-depth content to newspapers, giving new media the priority to non-exclusive material but offering newspapers the priority to exclusive information. Discords occasionally occurred between the managements of newspaper offices and new media centre nonetheless.
Shangjia kenéng yijing dì yi cì shiyòng ta. Tamen zài fangwèn mòsheng hé yáoyuan dì dìfang de jinglì cìjile yuyán, zongjiào, xísú hé sixiang zhi jian de bijiào. Zhège duan shouxie de jiaoben chuàngzàole yi zhong gèngjia jinglì chongpèi hé tànsuo de shèhuì lèixíng. Yixie xúnwèn zhe shì fazhan zìji de sixiang xìtong de zhéxué jia. Suízhe xiezuò zhishì guangfàn chuánbò, qí shìjué biaojì chéngwéi hàoqí xin de duìxiàng, yóuqí shì zài jùyou qiángliè koutóu chuántong de shèhuì. Zhè zhong shèhuì cúnzài yú 5 shìjìde xilà chéngbang. Hé ma shi, jì dé bù dú, shì xilà rén liánhé de wénhuà juzhèn. Rán'ér, xiàng Hesiod,Aeschylus hé Sophocles zhèyàng de zuòjia ye zài xiànchang.
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