For all other experiments, analyses of iMN samples were performed with the statistical software package Prism Origin v.7.0a (GraphPad Software). The normal distribution of data sets was tested by the D’Agostino-Pearson omnibus normality test. Differences between multiple groups were analyzed using 1-way ANOVA with Tukey’s correction for all comparisons, unless the data were non–normally distributed for which nonparametric Kruskal-Wallis testing was used. Mean and standard deviation or standard error of the mean was used for normally distributed data sets, and the median and interquartile range were used for non–normally distributed data sets. Differences between 2 groups were analyzed using a 2-tailed Student’s t test, unless the data were non–normally distributed, in which case 2-sided Mann-Whitney testing was used. Significance was assumed at P < 0.05.


Although the effects of media convergence from a journalist perspective are waiting to be further examined, a comprehensive view of the influence of new media on news production has been achieved by Chinese scholars. Existing studies indicate that journalists’ attitude towards new media is complicated. On one hand, the use of the Internet and we-media, such as QQ, Weibo and Wechat, has been considered to boost the work efficiency of journalists, enhance the interaction between journalists and readers and increase the transparency of news production (Wu and Zhang, 2015). On the other hand, an increasing number of journalists are also inclined to attribute the loss of ‘journalistic ideal’ to multifarious pressures provoked by new media (Ding and Wei, 2014). Given the development of mobile Internet and prevalence of we-media since the beginning of the 21st century, information and opinions from netizens have gradually become a vital source of news for traditional media and the public (Wu and Zhang, 2015; Zhou, 2014), and the objectivity of news and journalists’ authoritativeness have been impaired (Bai, 2013).
Yóulǐkǎ (Eureka), Jiālìfúníyàzhōu -- Jì qùnián dì-sì bǎn de zhòngdà shēngjí zhīhòu, Wénlín Yánjiūsuǒ jīntiān yòu fābù le Wénlín 4.1.1 bǎn. Xīn bǎnběn kě zài www.wenlinshangdian.com huòqǔ. Wénlín 4.0 huò 4.1 bǎn de dāngqián yònghù kěyǐ miǎnfèi gēngxīn. Wèile ràng Wénlín Hànyǔ Xuéxí Ruǎnjiàn gèngjiā shíhuì, Wénlín Yánjiūsuǒ yǐjīng xuānbù, wánzhěngbǎn de jiàgé cóng 179 Měiyuán xiàtiáo zhì 99 Měiyuán, shēngjí fèiyòng cóng 49 Měiyuán xiàjiàng zhì 29 Měiyuán. Xīn yònghù zhǐ xū 99 Měiyuán jí kě gòumǎi Wénlín (hán CD, 119 Měiyuán wàijiā yùnfèi); Wénlín 3.x bǎnběn de yònghù gòumǎi kě xiàzài de shēngjí wénjiàn zhǐ xū 29 Měiyuán (hán CD, 49 Měiyuán wàijiā yùnfèi). Xiàzài bǎnběn hé CD bǎnběn dōu kě zài www.wenlinshangdian.com shàng huòdé, yě kě tōngguò Hànyǔ ruǎnjiàn língshòushāng gòumǎi.
To determine if increased glutamate receptor levels might be a conserved mechanism that drives hyperexcitability in multiple forms of ALS, we examined levels of the NR1 NMDA receptor subunit in neurites of control, C9ORF72 ALS, and sporadic ALS iMNs by immunostaining. Similarly to our previous study, C9ORF72 iMNs possessed significantly more NR1+ punctae on neurites than control iMNs (Figure 4, A and B; 2 controls and 2 C9ORF72 ALS patients, and ref. 4). Colabeling with a MAP2-specific antibody verified that the NR1+ punctae that were increased in abundance were localized on dendrites (Supplemental Figure 4, A and B). Interestingly, sporadic ALS iMNs also displayed more NR1+ punctae on neurites than control iMNs (Figure 4, A and C, and Supplemental Figure 4, C–H; 2 controls and 6 sporadic ALS patients). Calcium imaging confirmed that C9ORF72 and sporadic ALS iMNs experienced more calcium transients than controls in response to glutamate, indicating that they may be more sensitive to excitotoxicity (Figure 4, D and E; 3 controls, 3 C9ORF72 ALS patients, 1 sporadic ALS patient). Thus, both C9ORF72 and sporadic ALS iMNs display increased NR1 levels, which could reflect a shared mechanism of increased susceptibility to excitotoxicity.
Because glutamate receptor homeostasis is maintained in part through vesicle trafficking (33, 34) and we had observed that 3K3A-APC exerted potent effects on autophagosomal and lysosomal pathways in iMNs, we determined if 3K3A-APC could normalize glutamate receptor levels in ALS patient–derived motor neurons. Indeed, 3K3A-APC reduced the number of NR1+ punctae on C9ORF72 and sporadic ALS iMN neurites to control iMN levels (Figure 4, A–C, and Supplemental Figure 4, A and B; 2 controls, 2 C9ORF72 ALS, and 6 sporadic ALS patients). Using surface protein biotinylation, we were able to purify surface-bound proteins from iMNs (Figure 4, F–I, and Supplemental Figure 4I). Immunoblottting confirmed that 3K3A-APC reduced membrane-bound NR1 levels on C9ORF72 and sporadic ALS iMNs (Figure 4, F–I, and Supplemental Figure 4, J–M), but not control iMNs (Supplemental Figure 4, N–Q). 3K3A-APC treatment did not alter total NR1 levels, but specifically reduced the amount of surface-bound NR1 on ALS iMNs (Supplemental Figure 4, J–M and R–W). 3K3A-APC also did not alter total NR1 levels in control iMNs (Supplemental Figure 4, X–Z). Thus, 3K3A-APC normalizes NR1 levels on C9ORF72 and sporadic ALS iMNs.
Ji zhou hòu, zhulì'an cóng mìxixibi huíláile. a shén lì yeshì. ou'er ta huì da diànhuà wèn wo shìfou keyi dài ta qù yixie dìfang. Wo zài Walgreen de shangdiàn ná qile Julianne de gongzi. Zhipiào wèi 383.08 Meiyuán, di yú dàikuan é. Yinwèi ta de qianmíng bìxu zài zhipiào shàng, wo zuìzhong méiyou shou dào zhè bi qián. Ta xiànzài jìnle wo ji bai meiyuán, chaochule wo cóng Ashley danrèn zu kè de sunshi, dànshì dang ta da diànhuà shí, wo zong shì hen xingfèn.
Zài xi lì yà cóng míngnísudá zhou ban chulái zhihòu, lián duì women de hunyin bìng bù manyì. Dang wo bù yuànyì zuò zìji xiang zuò de shìqíng shí, ta yiwéi wo shì “zìsi” de. Lián xiang luyóu shìjiè. Ta xiwàng wo nénggòu zài beijing shenghuó gèng cháng shíjian. Wo zhichu, wo de zulìn yèwù ba wo bang zài míng ní abo lì si dìqu. Dang wo xiàng Sheila huò ta de xiongdì Alan jiao chu huò jiè qián shí, ta huì bàoyuàn wo duì ta de lìnsè. Yóuyú ta bù zài zài Target gongzuò, ta you gèng duo de shíjian zuò zài diànshì ji qián, kànzhe ta mèimei sòng lái de DVD huò lùxiàngdài shàng de zhongwén xì. Ta cuòguòle xi lì yà
A total of 300 journalists from 11 newspapers (i.e., Xiamen Daily, Xiamen Evening News, Haixi Morning Post, Strait Herald, Fujian Daily, Strait Urban News, Fuzhou Daily, Fuzhou Evening News, Quanzhou Evening News, Southeast Morning Post and Strait Urban News (South Fujian Edition)) in the cities of Xiamen, Fuzhou and Quanzhou responded to the survey. After eliminating the ones in which over half of the questions were left unanswered, 274 copies of effective questionnaires were retrieved (completion rate = 91.3%). Two researchers input the data into SPSS19.0 and performed mutual proofreading to correct the errors in the manual input process. The findings were obtained through analysis of variance (ANOVA) and correlation analysis.

April 2019: Our paper (with Kejun) ‘‘Detecting Overlapping and Correlated Communities: Identifiability and Algorithm’’ has been accepted to ICML 2019! This work proposes a new community detection method that has correctness guarantees for identifying the popular mixed membership stochastic blockmodel (MMSB). Many existing methods rely on the existence of ‘‘pure nodes’’ (i.e., nodes in a network that only belong to one community) to identify MMSB. This assumption may be a bit restrictive. Our method leverage convex geometry-based matrix factorization to establish identifiability under much milder conditions.


The Chinese media have undergone commercial liberalization during the reform era. Interviews with media practitioners reveal that media reform has brought about three different types of newspapers that differ with respect to their degree of commercial liberalization. Based on a natural experiment during the anti-Japanese protests in Beijing in 2005, this article shows that urban residents found more strongly commercialized newspapers more persuasive than less commercialized newspapers. Provided that the state can enforce press restrictions when needed, commercial liberalization promotes the ability of the state to influence public opinion through the means of the news media.

Over the course of media reform in the past four decades, economic and technological logic has definitely been significantly adherent to political logic, thereby exerting an influence under the latter’s framework. For example, propaganda has been given a high priority as a function that the Chinese media must perform throughout the process of media reform. Nevertheless, the tension between profiting and propaganda, market and state provides space for the strategic development of the media industries within China.
Wénlín ABC EDOC shì zài ABC gǔdài Hànyǔ cíyuán cídiǎn de jīchǔ shàng biānxiě, gāi cídiǎn shì Xiàwēiyí Dàxué Chūbǎnshè rè pěng de ABC Xìliè zhīyī; tā háishi dì-yī kuǎn kě sōusuǒ gǔdài Hànyǔ zìyuán de diànzǐ cídiǎn, qí zhòngdiǎn zàiyú yǔyīn hé Zhōnghuá wénhuà gēnyuán de hányì. Jīngguò jīngxīn shèjì, shìyòng yú fēi zhuānyè rényuán hé zhuānyè rénshì, zhè bù cídiǎn fēicháng yìyú shǐyòng, nèiróng yǐ zìmǔ shùnxù biānpái, yōngyǒu zhòngduō chuàngxīn de císhū gōngnéng. Měi ge cítiáo tígōng yī ge huò duō ge kěnéng de cíyuán, fēnjiě fāyīn hé qítā xiāngguān shùjù. Cídiǎn jiāng cífǎ shàng yǒu guānlián de cízǔ héwéi “cí xì”, yǐbiàn gèng qīngxī de chǎnshì yǔ zhī guānlián de pàishēngcí hé qítā cíyuán biànhuà. Wénlín ABC EDOC cídiǎn diànzǐ bǎn nèihán yī piān jùyǒu zhòngyào yìyì de zuòzhě xù, jièshàole zuòzhě duì Hànyǔ zài Yàzhōu de yǔyánxué dìwèi kànfǎ, xiángshùle Hànyǔ yǔyán jíqí yuánxíng zuìchū de yǔyīn hé cífǎ shǔxìng.

In the early stages after the foundation of China, domestic journalists assumed the primary role of ‘propagators’. From the 1980s to the 1990s, China’s journalists have started to undertake other roles, such as ‘information providers’, ‘information interpreters’, ‘advocators’ and ‘profit makers’. Evidently, their professional roles have become increasingly diversified. In recent years, domestic journalists have gradually ‘returned to the essence of journalism’ in their selection of professional roles (Chen and Jiang, 2008). Most professional journalists have identified with the objective and neutral role of an ‘information provider’ (Zhang and Wu, 2014).


Zhè zhong tísheng dào changhé de nénglì you yigè jingshén céngmiàn. Jiézòu, xiàng xilà zhéxué de lixiang, you yidìng de tiansheng de pinzhí. Zhishì dì xìngzhì kenéng, kenéng, bangzhù yourén shengchan ta de xuqiú. Zài yu dingjí yùndòngyuán de fangtán zhong, xinli xué jia yijing xuéhuì rèn shì nénggòu dài lái gaofeng biaoxiàn de mou xie jìshù. Lìrú, keshìhuà jìshù bangzhù yùndòngyuán jingshén shàng jízhong yú shoutóu de rènwù. Gao'erfu qiú shou jiékè·níkè láo si (Jack Nicklaus) shuo, ta zài chángshì shèmén zhiqián jingcháng huì zài ta tóunao zhong “kàn diànying”.
59 95% confidence interval ranged between 55 and 90%. Old Wang is only 33% likely to read commercialized papers (95% confidence ranged between 24 and 42%). A dummy variable for having travelled to countries in Europe or North America was dropped from the analysis, because it predicted the use of commercialized papers perfectly. Results can be retrieved from the author upon request.

For all other experiments, analyses of iMN samples were performed with the statistical software package Prism Origin v.7.0a (GraphPad Software). The normal distribution of data sets was tested by the D’Agostino-Pearson omnibus normality test. Differences between multiple groups were analyzed using 1-way ANOVA with Tukey’s correction for all comparisons, unless the data were non–normally distributed for which nonparametric Kruskal-Wallis testing was used. Mean and standard deviation or standard error of the mean was used for normally distributed data sets, and the median and interquartile range were used for non–normally distributed data sets. Differences between 2 groups were analyzed using a 2-tailed Student’s t test, unless the data were non–normally distributed, in which case 2-sided Mann-Whitney testing was used. Significance was assumed at P < 0.05.


Zài guójia bólanhuì qíjian, wo qiaole lín dá de mén, wèn ta shìfou you xìngqù hé wo yiqi qù guójia bólanhuì. Ta kuàisù de kànzhe wo shuo ta huì “tongguò”. Dànshì hòulái de ji gè xingqí, lín dá qiaole qiao mén. Ta hé ta de bànlu láo la gang cóng jiazhong bèi gan zoule. Ta xuyào yigè zhùsù dìdian. Shì de, wo zài lóu shàng de fángjian li you fángjian.
Though holding relatively positive attitude towards new media as revealed in the survey, local journalists in Fujian’s press groups did not embrace the convergence with new media enthusiastically. The main change brought about with the convergence, after the establishment of the new media centre and the reconstruction of the news production workflow within Fujian’s press groups, is the journalists being currently expected to feed news to the centre so that the gap of contents for the new media outlets will be filled. During the interviews, directors, editors and journalists unanimously agreed that media convergence enhanced the requirements for timeliness and accuracy of news production as well as increased the intensity of journalists’ workload, but failed to radically alter the methods of selecting and writing news, thereby bearing no significant influence on journalists. A few journalists indicated their willingness to commit immediately to the convergence of news production; however, other journalists refused to cooperate with the new media centre.
The last two sections show some potential changes in the dominant path of media convergence adopted by the local press industry. Existing studies indicate that institutional and organisational factors considerably influence the journalists’ perception of their professional roles (Tao and Zhang, 2014; Wu et al., 1996; Zhang and Wu, 2016). Long-term attention is equally worthwhile with regard to whether the future structural adjustment of the local press industry in the area of media convergence will change the journalists’ identification of their roles.
The differences in the reactions to the encouragement between young/junior and old/senior journalists follow the same logic. Unlike young and junior journalists who hold contract positions, the old and senior journalists have substantial security from their authorised status (Bianzhi), thus rarely suffer from the effects of the living pressure of newspapers regarding current journalistic practices.
Taking advantage of Fuchai's expedition to his north to defeat Qi, Goujian led his army and successfully attacked the Wu capital, killing the Wu crown prince, You. In the 24th year of his reign (473 BC), Goujian led another expedition against Wu, laying siege to the capital for three years before it fell. When a surrender from Fuchai was refused, Fuchai committed suicide and Wu was annexed by Yue. After his victory, Goujian ruthlessly killed Fuchai's scholars, even those who helped him (including Bo Pi), not allowing himself to make the same mistake Fuchai had made by sparing the lives of his enemies. However, Goujian would not stop there; he would later force Wen Zhong to commit suicide; Fan Li, knowing that Goujian was a man who can share woe but not wealth together, left Goujian after the defeat of Wu.

One of the goals of media convergence in the reconstruction process is to modify the journalist–editor relationship by veering from ‘journalist-centred’ to ‘editor-centred’, such that journalists shall mainly undertake the role of information gatherer, whereas editors perform the role of information synthesiser. Regarding real news production, most new media centre editors are recruited from the members of society who are familiar with new media but inexperienced in news gathering and editing; thus, they are mere ‘stevedores’ rather than ‘processors’ of texts. Given that editors lacked the required qualifications, journalists were forced to undertake additional tasks (e.g., verifying information and converting statements from frontline journalists into text) that should have been performed by editors.

Liánrì qi yuè wu rì cóng beijing fanhuí míngnísudá zhou. Women liang rén yú qi yuè èrshí rì (xingqí'èr) fei wang xiyatú, zài huáshèngdùn bèi lái wéi shìchá ta de péngyou lú nushì. Jingguò 3 tian de fangwèn, women huíláile. Bùjiu zhihòu, lián fei dào tiánnàxi zhou nà shí wéi'er, bàifangle ta de mèimei wèi gé hé en gé de zhàngfu chá kè·pà er. Wo zài qi yuè sanshíyi hào fei wang huáshèngdùn gelúnbiya tèqu, huìjiànle cóng nà shí wéi'er jiàshi de lián héwén qí. Women yiqi kai che qù mi'er fú dé. Ránhòu san tian, women canguanle fèichéng, niuyue shì hé niu hei wén kangnièdígé zhou. Liánxì hen shengqì. Ta ba yuèchuhuí dào beijing. Dangrán, wo baochí xila de huáiyùn shì yigè mìmì.

Xila yu shènglùyìsi de lì nà de péngyou zài yiqi. Ta zài nàli shengbìngle, bùdé bù qù yiyuàn. Xila shuo, pèi sen de xinzàng zài nà duàn shíjian jihu tíngzhile tiàodòng. Suirán liang rén dou nénggòu huifù, dàn Payson xiànzài de tizhòng bùzú, ér Sheila de bèibù geile ta hen dà de tòngku. Ta maile yigè dà guahào lái ràoguò. Xìngyùn de shì, yisheng gàosù xila, ta xuyào chifàn, huafèi dàliàng de shíjian shuìjiào. Fanhuí mìsuli zhou de luxíng yi quxiao.
Wo wúfa dédào yisheng de dáfù, shuomíng wo qizi zài huáiyùn qíjian siwáng de kenéng xìng, háishì you biànxíng de ying'ér. Yexu zhè shì bù qiè shíjì de wèntí. Zài suíhòu yu xi lì yà de duìhuà zhong, wo juédìng zhè zhong qíngkuàng shì wúwàng de. Dangrán, wo bùnéng gàosù yisheng, tamen céngjing jinggàoguò kenéng daozhì liánlián siwáng de chéngxù. Wo gàosù xi lì yà wo tóngyì zài shengyù zhensuo tíngzhi zhìliáo.
Yìnshua de yinrù yu duì gudian luóma hé xilà zuòjia dezhe zuò chóngxin gan xìngqù. Gudian xilà hé luóma wénhuà de zuòpin bèi rènwéi shì youxiù wénmíng de chanwù, zhídé fangxiào. Shèngjing zhong yeyou lèisì de zànmei. Xiàng yi la si mó hé mading·lù dé zhèyàng de xuézhe yòng lading yu huò xilà yu chuàngzàole shèngjing de xin yìben, xiwàng néng xiàng rénlèi kenéng dì nàyàng duì yuánshi wénben yiyàng zhenshí.

(A) Overview of the experimental procedure for testing the ability of 3K3A-APC to reduce DPR levels in the hippocampus of C9-BAC mice. (B–D) The effect of 10 nM inactive 3K3A-APC or 3K3A-APC on the level of poly(GR)+ punctae in the dentate gyrus of C9-BAC mice. Mean ± SD of the number of poly(GR)+ (B), poly(GP)+ (C), and poly(PR)+ (D) punctae per cell; each data point represents a single cell. Cells quantified from 3 mice per condition, 1-way ANOVA with Tukey’s correction for all comparisons. Scale bars: 10 μm. Dotted lines outline cell bodies. Neuronal area was determined by manual outlining in ImageJ on the basis of the staining pattern provided by TUJ1 or MAP2. (E) Overview of the experimental procedure for inducing NMDA injury in the hippocampus and testing the ability of 3K3A-APC to mitigate this injury. (F and G) The effect of 0.2 μg of 3K3A-APC delivered in a volume of 0.3 μL on NMDA-induced hippocampal injury in C9orf72+/+ and C9orf72+/– mice. Mean ± SEM of n = 3 mice per condition, 1-way ANOVA with Tukey’s correction across all comparisons. Red dashed lines outline the injury sites (F). Vehicle control conditions were published in a previous study (4). (H and I) Immunostaining (H) and quantification (I) of NR1 levels in C9orf72+/– mice treated with vehicle or 0.2 μg of 3K3A-APC delivered in a volume of 0.3 μL (n = 3 mice per condition, 72 cells quantified per condition). Each gray data point represents a single cell. Mean ± interquartile range. Mann-Whitney test.
Wo de shourù zhifùle women hunyin qíjian de dà bùfèn jiatíng zhichu, ér wo de qizi de shourù shì cháozhe zhubao huò ta xiang yào de rènhé qíta de dongxi. Wo muqin mai de yixie you jiàzhí de danmài shèngdàn sháo chuláile. Wo de qizi shouxian shuo ta bù zhidào sháozi zài nali, dànshì dang wo tíjiao baoxian sunshi suopéi shí, ta shuo tamen shì zài “cúnchú”. Shougòu cáichan sìhu shì ta duì zhè xiàng hunyin de zhuyào xìngqù.
(a) Sample distance matrix using hierarchical clustering with Euclidian distance metric of total transcriptome of each sample. (b) Principal component analysis of total transcriptome of each sample. (c) Clustered heat map showing normalized expression levels of top 40 genes sorted by adjusted p-value. All analyses were performed using DEseq2 in R (Supplementary Table 3).
Wo faxiàn zài hùliánwang shàng jingcháng bàolù sèqíng nèiróng, xueruòle wo shíshí zhíxíng de nénglì. Wo huì yijiànzhongqíng, yigè luoti de nurén, dàn wo de yinjing huì hen kuài biàn ruan. Yexu zhè shì niánlíng de jiéguo. Wo cónglái méiyou shiyòng weige huò lèisì di yàowù. Bùguò, wo ye rènwéi, dang wo zài sèqíng wangzhàn shàng huafèi gèng duo de shíjian shí, wo duì zhenzhèng xìngyù de kewàng jiànjiàn xiaoshi. Zhè kenéng shì yinwèi hùliánwang túxiàng zài qínggan shàng manzúle wo. Zhège jinglì chéngle xiànshí de tìdài pin. Rúguo wo yi lìng yi zhong fangshì huòdé manzú, jiù bù zài keqiú xìng xíngwéile.
Jiéshù liang zhou hòu, wo shou dàole hali sen shèqu xiéhuì weiyuánhuì de yi feng chuánpiào, gai weiyuánhuì duì wo de jiànzhú wù de fànzuì gandào guanqiè. Women dìqu de shì yìhuì dàibiao yijing zàichang. Zài huìyì shàng, wo shìtú jieshì shuo, wo yijing yù dàole zuhù, jiù rúhé jiejué zhèxie wèntí zhengqiú yìjiàn. Zhè bù fúhé weiyuán de yìjiàn. Tamen cheng wo wèi “tianzhen” hé “bùshìhé guanli chuzu wùyè”. Weiyuánhuì yaoqiú wo lìjí quzhú suoyou zuhù, bìng jiang tamen tìhuàn wèi jingguò zixì shaixuan de rényuán. Wo gàosù tamen zhè shì wo de shì, ér bùshì ta de. Wo huì juédìng caiqu shénme bùzhòu. Bùguò, zuìhòu, wo tóngyì quzhú you bèi bu zuìfàn de jìlù.
“Transforming an Old Qiaoxiang: Impacts of the Diaspora on Panyu, 1978-2000,”  presented at the Second International Conference for Institute & Libraries for Overseas Chinese Studies on “Transnational Networks: Challenges in Research and Documentation of the Chinese Overseas,” in Hong Kong, organized by the University Library System, The Chinese University of Hong Kong, and Ohio University Libraries, 13-15 March 2003.
dangrán zhège nu'ér gòu haole ta shì yigè you xiyin lì, congmíng, shànliáng, meilì de niánqing nuzi, duì jiatíng de xìnyù. Lìng yi fangmiàn, dang ta hé ta de muqin dì yi cì lái hé wo zhù zài yiqi shí, ta shíba suì. Yi nián gaozhong bìyè hòu, ta zài lìng yigè chéngzhèn shàng dàxué, ránhòu zài fèichéng jìnxíng yi nián de shèqu fúwù, ránhòu dào chéngrén shìyè, shouxian zuòwéi yi míng chéngwùyuán, ránhòu zuòwéi yuyán xué jia zhù zhù huáshèngdùn tèqu zài ta de chéngzhang zhong méiyou zhòngyào de zuòyòng. Wo ye méiyou shìtú yòng zìsi de fùmu liyóu jianchí ta. Háizi, dang tamen nénggòu, yinggai zìji chují. Yexu wo zhishì yigè yúchun de laorén, yinggai tíngzhi zìsi, jieshòu wo yijing yongyou de hao dongxi.
Wo liaojie dào, ka luó er hòulái ban jìnle yigè kenéng yóu tuìxiu haijun guanyuán yongyou de wa wa suo hú de fángzi. Zài èrshí shìjì jiushí niándài, yi wèi nìmíng de nánxìng jiào wo wèn ka luó er shìfou céng zhùyuàn, dàgài shì jingshénbìng. Wo shuo wo méiyou zhèyàng de zhishì. Láidiàn zhe bù huì tòulù ta de míngzì. Diànnao sousuo biaomíng, ka luó er xiànzài keyi zhù zài yalìsangnà zhou de méi sà, nàli ta de fùmu yijing tuìxiule.
Males and females accounted for 49.6% and 50.4%, respectively, of the total number of respondents. The respondents with a degree of and below junior college accounted for 1.8%, those with bachelor’s degree accounted for 83.5% and those with a master’s degree or above accounted for 14.7%. Among the respondents, 33.2% came from party organs, whilst 66.8% came from metropolis newspapers. The mean age of the respondents was 31 years old (M = 30.63, SD = 6.35) and the mean number of years at work was 8 (M = 7.62, SD = 6.50).
An hòu, you ji nián de shíjian, wo méiyou rènhé yigè rén, huòzhe rúguo wo zhèyàng zuò, hen kuài jiù huì ràng guanxì qù. Wo biàn dé bèi zhèngzhì yuányin suo xiyin. Dì yigè shì nánrénquánlì de shìyè. Mei dang yigè nurén bàoyuàn bàolì shí, jingfang bù yìng gai zìdòng dàibu zhè míng nánzi. Fùnu jiefàng yùndòng de dingfeng suirán yijing guòqùle, dàn yeyou lèisì de tàidù zhèngzài tongguò sifa jigòu hé qíta zhèngfu jigòu.
Treatment with the small-molecule PAR1 antagonist alone did not affect the survival of sporadic ALS iMNs (Supplemental Figure 6, K–P; 6 sporadic ALS patients), but the PAR1 antagonist blocked the ability of 3K3A-APC to rescue sporadic ALS iMN survival (Figure 5I and Supplemental Figure 6, Q–V; 6 sporadic ALS patients). Thus, 3K3A-APC can rescue C9ORF72 and sporadic ALS iMN survival through activation of PAR1.

Jinnián shì 2009 nián, dangshí wo de ayí cóng jiazhou qùshìle. Yóuyú zhàngfu yu tamen youguan, ta bèi mái zài yìndì'annà zhou nán ben dé de Studebaker jiatíng yinmóu zhong. Wo fei dào zhijiage, zule yi liàng che, jihu méiyou zài nán ben dé canting ju háng jiatíng jùhuì. Zài qiutian, wo zài beijing bàifangle lián. Women duì nèiménggu jìnxíngle zhoumò yóulan. Liú zài yigè yuán xíng de xiaowu. Wo ganmàole, yexu shì liúgan. Huí dào meiguó, wo yi zì chuàng de “xin zunyán pàiduì” paole míng ní abo lì si shì zhang. Xuanju jiéguo lìng rén shiwàng.

Zài 2009 nián de zuìhòu yigè yuè, wo kaishi chuàngjiàn yigè míng wèi “BillMcGaughey.Com” de wangzhàn, zuòwéi wo wangzhàn zuòpin de jiaodian. Wo cóng niánqing rén nàli huànle rongcháng de shougao. Gèrén gùshì jiang shì wo de zhuancháng. Rán'ér, liánxù bùduàn de bàoyuàn wo de zìsi. Zhè ji tian, women hen shao zài tóngyi zhang chuángshàng shuìjiào. Lián zài lìng yigè danwèi li you zìji de wòshì. Ta huáiyí wo kenéng huàn you àizibìng. Rán'ér, ta yuè lái yuè duo de hua zài zhongguó, yibiàn yisheng nénggòu jiancè bìngqíng, kàn kàn áizhèng shìfou yijing fanhuí.
Wo ba wo de xin qizi hé nu'ér dài dào binxifaníya zhou de mi'er fú dé, wo cóng fùmu jìchéngle yi suo fángzi. Xi lì yà huì qù nàli de gaozhong háishì zài míng ní abo lì si? Lián shuo ta xihuan zhù zài yigè chéngshì. Zài mi'er fú dé liang tianhòu, women kaiche zhí ben míngnísudá, kaishi xin de shenghuó. Xi lì yà bèi pìn wéi míngnísudá zhou beibù de pàtèlikè·henglì gaozhong de zishen rénshì. Ta zài yingguó niújin fùjìn de guójì xuéxiào dùguòle yi nián de shíjian, jiangle chusè de yingyu. Lián zhunbèi xin shenghuó qu, shìyìng meiguó shenghuó, méiyou lìjí jìhuà. Yóuyú canyùle yèzhu xiaozu, wo jianduan de shì míng ní abo lì si shì shì zhang de hòuxuan rén. Wo de xin jiatíng bèi jièshào gei lóuzhu péngyou.
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