When the Tianqi Emperor died in October 1627, he had no surviving heir (his last son died a year prior during the mysterious Wanggongchang Explosion). As the emperor's brother, Zhu Youjian, then about 16 years old, ascended the throne as the Chongzhen Emperor.[2] His succession was helped by Empress Zhang (widow of the Tianqi Emperor), despite the manoeuvres of the chief eunuch, Wei Zhongxian, who wanted to continue to dominate the imperial court.[3] From the beginning of his rule, the Chongzhen Emperor did his best to stem the decline of the Ming dynasty. His efforts at reform focused on the top ranks of the civil and military establishment. However, years of internal corruption and an empty treasury made it almost impossible to find capable ministers to fill important government posts. The emperor also tended to be suspicious of his subordinates, executing dozens of field commanders, including general Yuan Chonghuan, who had directed the defence of the northern frontier against the Manchu (later known as the Qing dynasty). The Chongzhen Emperor's reign was marked by his fear of factionalism among his officials, which had been a serious issue during the reign of the Tianqi Emperor. Soon after his brother's death, the Chongzhen Emperor immediately eliminated Wei Zhongxian and Madam Ke, as well as other officials thought to be involved in the "Wei-Ke conspiracy".[4]
In surveying pharmacological agents that might be capable of promoting autophagosome formation in C9ORF72 ALS iMNs, we identified activated protein C as a possible candidate. Activated protein C is an endogenous blood serine protease with both anticoagulant and cytoprotective activities, that latter of which is mediated by the activation of PAR1 through non-canonical cleavage (19). Zhong and colleagues previously showed that activated protein C treatment can rescue neurodegeneration in SOD1G93A mice (20) and promote autophagosome formation in murine lung epithelial cells (21). However, it remained unclear if activated protein C could stimulate autophagosome formation in C9ORF72 ALS iMNs, rescue neurodegeneration in non-SOD1 forms of ALS, or rescue neurodegenerative processes in patient-derived motor neurons. To test these possibilities, we used 3K3A-APC, an engineered form of activated protein C in which 3 active-site lysine residues required for degrading factor Va and VIIIa are changed to alanine, resulting in a 90% reduction in anticoagulant activity but full retention of PAR1 activation ability (22). 3K3A-APC is well tolerated in mice under chronic dosing at levels that activate PAR1 within the central nervous system, and short-term peripheral administration is safe in monkeys (20, 23, 24). As a negative control for these studies, we used heat-inactivated 3K3A-APC.
An intronic GGGGCC repeat expansion in C9ORF72 is the most common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), but the pathogenic mechanism of this repeat remains unclear. Using human induced motor neurons (iMNs), we found that repeat-expanded C9ORF72 was haploinsufficient in ALS. We found that C9ORF72 interacted with endosomes and was required for normal vesicle trafficking and lysosomal biogenesis in motor neurons. Repeat expansion reduced C9ORF72 expression, triggering neurodegeneration through two mechanisms: accumulation of glutamate receptors, leading to excitotoxicity, and impaired clearance of neurotoxic dipeptide repeat proteins derived from the repeat expansion. Thus, cooperativity between gain- and loss-of-function mechanisms led to neurodegeneration. Restoring C9ORF72 levels or augmenting its function with constitutively active RAB5 or chemical modulators of RAB5 effectors rescued patient neuron survival and ameliorated neurodegenerative processes in both gain- and loss-of-function C9ORF72 mouse models. Thus, modulating vesicle trafficking was able to rescue neurodegeneration caused by the C9ORF72 repeat expansion. Coupled with rare mutations in ALS2, FIG4, CHMP2B, OPTN and SQSTM1, our results reveal mechanistic convergence on vesicle trafficking in ALS and FTD.

Accordingly, the following questions must be answered in the context where the tension between newspapers and new media departments seems persistent: What will be the destiny of metropolis newspapers if they deviate from converging news production? Will other types of newspapers, due to their loss of market competitive edge to new media outlets, shift to the role of ‘Party Mouthpiece’ that has previously been performed by the party organs? Evidently, these questions can be explored in future research.
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Suirán zhulì'an zài mìxixibi zhou, wo de qiánqi xila, you yitian dàole wojia, women zuò'ài. Wo hen nándang wo zài limiàn shèjing shí, xila shuo cónglái méiyou zhème duo shui. Julianne dì xìngbié qiánjing kenéng yijing qidòngle wo de bèng. Dang wo hé Sheila fasheng xìng guanxì shí, wo bìng méiyou xiangdào ta, ér shì zài xiàyìshí zhong Julianne kenéng yijing zhunbèi haole wo de xíngwéi. Women shì yigè yì xiangbùdào de, zìfa de guanxì, wangwang shì zuì hao de. Zài hé che li qingsheng shuohuà de shíhòu, zài wo kàn lái, women shì zài yuehuì de.
Lentiviral expression of GFP or PR50-FLAG using a synapsin promoter in primary mouse cortical neurons. Immunocytochemistry was used to visualize PR50 localization (blue = DAPI, red = anti-FLAG, green = anti-MAP2). (e) Immunocytochemistry to detect the subcellular localization of exogenously applied synthetic PR20-FLAG (green = anti-FLAG) in HeLa cells with reduced levels of Rab7 (Rab7-i.1) using CRISPR-i (blue = DAPI, magenta = LAMP1 (lysosomal marker). 1 µM PR20 was added to cell culture media for 1hr. before cells were fixed and subjected to immunocytochemistry.
Zhulì'an shuo, ta jìhuà ban dào mìxixibi beibù de kèlakè si bao fùjìn, kàojìn a shén lì de fùqin. Ta hé a shén lì zài nàli de yigè xiao zhèn zhaodàole yi jiàn gongyù. Zhulì'an rènwéi ta kenéng huì zài míngnián qiutian zài kèlakè si bao de shèqu xuéyuàn shàngkè. Ta wèn wo shìfou shou dàole Ashley de sì yuèfèn de 208 meiyuán de MFIB zhipiào. Wo yijing méiyou qiánle. Wo cóng zìdòng qukuan ji shouhuí 200 meiyuán, zài tóurù 8 meiyuán, bìng jiao gei zhulì'an. Zhè jiang bèi yòng zuò gong chepiào, ràng ta jiarù mìxixibi zhou de a shén lì. Wo hé tamen de zhànghù shì píngdeng de.
The survey (see Table 2) indicates that from the viewpoint of local journalists in Fujian, new media has generally expanded the sources of news and facilitated contact with news-related groups. However, new media has also raised considerably high requirements for journalists’ expertise and spawned fierce peer competitions. Moreover, the respondents relatively agreed with the influences of new media in terms of enhancing journalists’ knowledge about the audience, although they disagreed with the belief that new media has marginalised news gathering and editing. The respondents took relatively positive attitudes towards the overall influences of new media on news production.
Oct. 2019: Trung Vu is awarded the Best Student Paper Award (second prize) at IEEE International Workshop on Machine Learning for Signal Processing, October 13-16, 2019 Pittsburgh, PA, USA! The award is given to a collaborative paper of Trung Vu, Raviv Raich and Xiao Fu titled ‘‘On Convergence of Projected Gradient Descent for Minimizing a Large-scale Quadratic over the Unit Sphere’’. Congratualations, Trung!
Women méiyou háizi, yinwèi wo de qizi you zigong nèi mó yì wèi zhèng, daozhì bù yù zhèng, yexu shì yinwèi ta zài dì yi cì hunyin zhong shiyòng bìyùn yào. Women qùle dàxué de zhensuo kàn yixué shàng kenéng huì zuò shénme. Ka luó er faxiàn zhège zhengti de jingyàn lìng rén yànwù, chìluoluo de shùfù zài jianchá tái shàng de shèbèi shàng. Ta zhizé wo yaoqiú ta huáiyùn.

Women de diànzi yóujiàn taolùn jìnzhan dào ta ba fùjìn de kafei diàn mìngmíng wèi huìyì dìdian. Zhiyou women yuehuì de shíjian dì yi cì jiànmiànle. Wo fachule yigè xúnwèn, dàn méiyou huífù. Si ba dá zhànshìtúrán chénmò yexu ta de zhàngfu yijing liaojie dào women de mìmì duìhuà, bìng caiqu bùzhòu zuzhi huìyì. Yexu ta zhèngzài hé wo yiqi wán wúlùn rúhé, zài fasòng chóngfù de xiao xí zhihòu, wo zài ye méiyou cóng zhège nurén nàli ting dào.

The Chinese media have undergone commercial liberalization during the reform era. Interviews with media practitioners reveal that media reform has brought about three different types of newspapers that differ with respect to their degree of commercial liberalization. Based on a natural experiment during the anti-Japanese protests in Beijing in 2005, this article shows that urban residents found more strongly commercialized newspapers more persuasive than less commercialized newspapers. Provided that the state can enforce press restrictions when needed, commercial liberalization promotes the ability of the state to influence public opinion through the means of the news media.


The recruitment of interviewees was conducted for two rounds. Given the demonstrative effect of the media convergence of the Xiamen Daily Group within the province and even the entire industry, the authors contacted seven media practitioners from this organisation to undergo the first round of interview. Consequently, one director, one editor and five newspaper journalists were involved as interviewees in this round. After developing a preliminary knowledge of the opinions of the Xiamen Daily Group journalists towards media convergence, the authors conducted a second round of interview. Three directors, three editors and seven journalists were recruited as interviewees from several other press groups, including Fujian Daily Group, Fuzhou Daily News Press and Quanzhou Evening News Press, thereby promoting the diversity of the interviewees in the aspect of age, years at work and newspaper type. Except for one journalist from the Fujian Daily Group who was interviewed via telephone, all the 19 others underwent face-to-face interviews (Table 1).


Jiéshù liang zhou hòu, wo shou dàole hali sen shèqu xiéhuì weiyuánhuì de yi feng chuánpiào, gai weiyuánhuì duì wo de jiànzhú wù de fànzuì gandào guanqiè. Women dìqu de shì yìhuì dàibiao yijing zàichang. Zài huìyì shàng, wo shìtú jieshì shuo, wo yijing yù dàole zuhù, jiù rúhé jiejué zhèxie wèntí zhengqiú yìjiàn. Zhè bù fúhé weiyuán de yìjiàn. Tamen cheng wo wèi “tianzhen” hé “bùshìhé guanli chuzu wùyè”. Weiyuánhuì yaoqiú wo lìjí quzhú suoyou zuhù, bìng jiang tamen tìhuàn wèi jingguò zixì shaixuan de rényuán. Wo gàosù tamen zhè shì wo de shì, ér bùshì ta de. Wo huì juédìng caiqu shénme bùzhòu. Bùguò, zuìhòu, wo tóngyì quzhú you bèi bu zuìfàn de jìlù.
Dang nurén cóng wo nàli ná qián de shíhòu, wo hen danxin wo bèi piànle. Wo shì yigè yúchun de laorén jiyu tóngyì. Nàgè nurén ba wo dàng zuò shì lìng yiduan dì shouduàn. Rán'ér, yu zhulì'an yiqi, wo ye rènwéi wo yuànyì gei ta qián - bùshì tài duo, ér shì yixie - shì wo guanxin de yigè jixiàng. Nánrén dì xìngbié jiang shì yigè jixiàng, fùnu yi zhèngquè de fangshì guanxin tamen. Fùnu de qián jiang shì yigè jixiàng, shuomíng zhège rén huì wèi ta zouchu lù. Suoyi women mei gèrén dou bìxu jiyu yidiandian ràng duìfang chéngzhang.
Liu Yu's mother Zhao Anzong (趙安宗) died on the same day that she gave birth to him, in 363. His father Liu Qiao (劉翹) later married Xiao Wenshou, although the date of the marriage is not known. She bore Liu Qiao two sons, Liu Daolian (劉道憐) and Liu Daogui (劉道規). Liu Yu was described to be highly deferential and respectful to her, as she was the only mother he knew. After he overthrew Huan Xuan, who seized the Jin Dynasty (265-420) throne in 403, he was created the Duke of Yuzhang, and she was honored as the Duchess Dowager of Yuzhang in 412. After he was created the Prince of Song in 419, she was honored as princess dowager. After he seized the Jin throne and established Liu Song in 420, she was honored as the empress dowager. By this point, Liu Yu was himself quite advanced in age (57), but he was described as so careful and so loving to her that he visited her every day without ceasing. After he died and was succeeded by his son Emperor Shao of Liu Song in 422, she was honored as grand empress dowager. She died in 423, and, pursuant to instructions that both she and Emperor Wu left, she was buried at the same site as Liu Qiao but not in the same tomb, as it would be difficult to conduct an imperial burial in the small tomb that Liu Qiao was buried.
Another explanation for journalists’ disinclination to provide news to the new media centre is the emerging conflict between the traditional and new media departments of the Fujian press industry. The main purpose of media convergence is to reconstruct the news production workflow and manifest the notion of ‘collection once, generation into varieties and dissemination in diversities’. Under the dominant path, the original departments of new media outlets are incorporated into the department of new media centre. From the perspective of newspaper office leadership, the timeliness of newspapers falls short of new media; thus, the latter is likely to further decrease the market of the former by intensifying the decline in newspaper readers. The leadership in Fujian’s press groups has been exploring various methods of press release, such as supplying basic facts to new media whilst providing details, background information and other in-depth content to newspapers, giving new media the priority to non-exclusive material but offering newspapers the priority to exclusive information. Discords occasionally occurred between the managements of newspaper offices and new media centre nonetheless.
(a) TMX2 protein reduction measured by immunoblot in K562 cells expressing Cas9 and sgRNAs targeting TMX2 or control sgRNAs (GAPDH levels were measured as loading control). (b) Enrichment of Tmx2 KO cells compared to WT in a K562 competitive growth assay after synthetic PR20 treatment. Cells measured 48 h after 10 µM PR20 treatment by flow cytometry. (c) Sample distance matrix using hierarchical clustering with Euclidian distance metric of total transcriptome of each sample. (d) Principal component analysis of total transcriptome of each sample. (e) Differential gene expression was determined using DEseq2, and the top differentially expressed genes as ranked by adjusted p-value were clustered using the R package pheatmap. Color indicates relative log2 fold change in normalized read counts from DEseq2. MA plot showing abundance of differentially expressed genes in red (adjusted p-value < 0.05) for pairwise comparisons of (f) control sgRNA neurons expressing PR50 vs GFP, (g) Tmx2 KO neurons expressing PR50 vs GFP, and (h) Tmx2 KO neurons expressing PR50 vs control sgRNA neurons expressing PR50 (Supplementary Table 3).

In general, similar to most local press groups in China, Fujian’s press groups have started advancing the convergence between newspapers and new media (i.e., in the news production area) only during the past two years without radically altering the existing system of the industry, that is, not touching the core zone of the media convergence–structure adjustment and business operation convergence. Therefore, the Fujian press industry makes a proper case of analysis for this study due to its typical nature in terms of convergence progress and path selection.
Wo 11 yuè 24 rì fei wang zhongguó, huale shí tian shíjian yu lián. Women jìhuà qù yuènán luxíng, dànshì yóuyú wo méiyou zhòng wén de wénjiàn, suoyi méiyou dédào jiejué. Women ye xiwàng qù tianjin yitian de luxíng, dàn méiyou. Women huale zhengzheng yigè shíjian zài beijing, zài nàli maile xin yanjìng, bìng pèile yìchi. Wo yigè rén huí dào míngnísudá zhou,12 yuè 5 rì língchén dàodá.
Dàgài zài zhège shíhòu, wo zhèngzài chuli yexu shì wo céngjing yù dào de zuì zaogao de zu kè. Ta shì yigè niánqing de danshen muqin, ta shì yigè nu tóngxìngliàn zhe. Ài lún pìnqing ta bangzhù qingjié gongyù. Ta xiàng wo baozhèng, ta bèi gùyòng bìng keyi zhifù zujin. Yijia jigòu zài 2009 nián 12 yuè de dì yigè yuè de zujin zhong zhifùle yibàn. Dànshì, yidàn ban jìnle zhè wèi zuhù,Ashley jiù kaishi bàoyuàn gongyù de wéixiu wèntí. Dang ài lún shìtú jiejué tamen shí, ta bàoyuàn wùpin zài ta líkai gongyù shí bèi tou zou. a shén lì rènwéi, zài suoyou de wéixiu wèntí dédào jiejué zhiqián, ta bù huì zhifù zujin. Ta jùjué qianyue zuyue. Yourén gàosù ta, rúguo méiyou qianyue, wo bùnéng héfa shou zu.
Wo huì wánquán tanbái de shuo zhège haochù jiùshì baobèi, bùshì làngmàn, ye bùshì hunyin de shùfù. Dangrán huì you yigè nurén zài nàli, yexu yigè nurén, hái méiyou zhaodào “zhèngquè de rén”, dàn danxin nàgè shíjian yijing bù fù cúnzàile chéngwéi muqin de jihuì. Zhè zhong lèixíng de rén kenéng duì wo suo tígong de dongxi gan xìngqù wo dangrán huì chéngdan wo fùmu zérèn de gongpíng fèn'é.
According to Mai (2012: 155–168), these two paths have rendered the cooperative interactions between the traditional and new media outlets far less frequent, if not totally suspended, and are likely to further alienate the newspapers from the original or latest new media departments. In other words, both paths create new administrative barriers whilst breaching or circumventing the original administrative barriers.
It is said that even in his lifetime a few of Wang’s characters or his signature were priceless. Down through the ages, aspiring students of that most basic yet highest art in China, calligraphy, have copied and preserved traces of his style. The most famous example of his writing is the Lantingxu (“Preface to the Poems Composed at the Orchid Pavilion”), which recorded a famous gathering of some 42 literary figures during the Spring Purification Festival of 353 ce to compose poems and enjoy the companionship of wine. Wang’s work was written in the xingshu, or “running script,” and has become the model for that particular style of writing. Among other generations of calligraphers in the family, Wang Xianzhi (344–386 ce), the youngest son of Wang Xizhi, was the most famous.
*  “Yuanyuan, changyu, xitong: Xinhua wenxueshi de jiegouxing xiezuo” 渊源、场域、系统:新华文学史的结构性写作 (Origins, Sites, Systems: Structural Writings of Singapore Chinese Literary History), presented at the 2nd Asia-Pacific Chinese Literature International Conference on “Writings of Chinese Literary History,” in Taipei, organized by the Department of Chinese Literature, National Taipei University, 5 October 2012.
Wang, Y., Fang, L. (2008). Yingyu yuedu jiaolv, yuedu celue he yuedu chengji xiangguanxing yanjiu [A study on the correlation among English reading anxiety, reading strategies, and reading performance]. Chongqing Keji Xueyuan Xuebao (Shehui Keyue Ban) [Journal of Chongqing University of Science and Technology (Social Sciences Edition)], 9, 221–222.Google Scholar

Lā Qiáolā (La Jolla), Jiālìfúníyàzhōu -- Wénlín Yánjiūsuǒ, Zhōngwén Xuéxí Ruǎnjiàn Wénlín hé CDL zìtǐ jìshù kāifāshāng, xuānbù tuīchū ABC Hàn-Yīng Yànyǔ Cídiǎn de ruǎnjiàn bǎnběn, yóu Yuēhàn Luósēnnuò (John S. Rohsenow) biānjí. Xiàndài Yǔyán qīkān duì Luósēnnuò (Rohsenow) cídiǎn de píngjià shì “dàigěi rén yúkuài tǐyàn, yìyú shǐyòng ... wèi pǔtōng Yīngyǔ dúzhě kāiqǐ le Zhōngguó mínjiān zhìhuì de bǎokù... duì rènhé jíbié de yǔyán xuéshēng hé rènhé xūyào jīngpì géyán de rén dōu shì jí jù xīyǐnlì qiě shífēn shòuyì de.” (89, 2005). Yóu Wénlín Yánjiūsuǒ (zhǐzhìbǎn de biānzhìzhě) kāifā de xīnbǎn ruǎnjiàn wèi xuéxí yànyǔ zhè yī bǎoguì zīyuán zēngtiān le xīn de wéidù. Gāi ruǎnjiàn bǎnběn yīng yǔ Wénlín Hànyǔ Xuéxí Ruǎnjiàn 4.1 huò gèng gāo bǎnběn jiéhé shǐyòng. Yōngyǒu Wénlín qiángdà de ABC diànzǐ cídiǎn de quánbù jíhé, yìwèizhe jiǎntǐ hé fántǐ Zhōngwén de dúzhě kěyǐ shíshí fǎngwèn gèzhǒnggèyàng de cítiáo yǐ tànqiú Luósēnnuò jiàoshòu jīngliáng fānyì de wēimiào zhī chù, bìng lǐjiě Zhōngwén yànyǔ gēng shēnkè de hányì. Shìyòng yú suǒyǒu liúlǎnqì de bǎnběn zhèngzài jījí kāifā zhōng. Zhè yī xīn diànzǐbǎn de shòuzhòng wéi pǔtōng Yīngyǔ hé Hànyǔ dúzhě, yǐjí rénlèixué, yǔyánxué, wénxué, shèhuìxué, xīnlǐxué, lìshǐxué zài nèi de gèzhǒng lǐngyù de zhuānjiā. Xīnbǎn Wénlín 4.1 huò gèng gāo bǎnběn de ruǎnjiàn kě zài wǎngshàng www.wenlinshangdian.com yǐ 19.99 Měiyuán huòdé.
Nèitian wanshàng, wo zuòle yigè guge sousuo zhu lì an dì míngzì jia shàng lánqiú. Shì de,“xing bào”2007 nián 12 yuè fabiaole yi pian guanyú ta de gùshì, tímù shì “zhunxing bù zài wú jia ke gui”. Wénzhang kaishi:“Gaozhong nusheng zonggòng huòdéle 75 fen, zài ben sàijì de qián liang chang lánqiú sài zhong huòdé 46 gè lánban, dàn hen shao yourén ting shuoguò ta. Bù kenéng, dàn ta fashengle. Zìcóng dà yi sàijì yilái, ta méiyou daguò xiàoche lánqiú, ér xiànzài, zuòwéi míng ní abo lì si àidísheng de yi míng zishen rénshì, ta zhèngzài zhìzuò gè zhong gè yàng de rén - baokuò dàxué zhaopìn rényuán - zhùyì lì. Bù hao de chéngji, yóuyú jiatíng shenghuó kùnnán, shì ta zuò xiàlái de zhuyào yuányin. Jiézhì 9 yuè zhongxún, ta zhù zài yigè wú jia ke gui de zhùsuo.“
Zài xi lì yà cóng míngnísudá zhou ban chulái zhihòu, lián duì women de hunyin bìng bù manyì. Dang wo bù yuànyì zuò zìji xiang zuò de shìqíng shí, ta yiwéi wo shì “zìsi” de. Lián xiang luyóu shìjiè. Ta xiwàng wo nénggòu zài beijing shenghuó gèng cháng shíjian. Wo zhichu, wo de zulìn yèwù ba wo bang zài míng ní abo lì si dìqu. Dang wo xiàng Sheila huò ta de xiongdì Alan jiao chu huò jiè qián shí, ta huì bàoyuàn wo duì ta de lìnsè. Yóuyú ta bù zài zài Target gongzuò, ta you gèng duo de shíjian zuò zài diànshì ji qián, kànzhe ta mèimei sòng lái de DVD huò lùxiàngdài shàng de zhongwén xì. Ta cuòguòle xi lì yà
Calcium imaging was performed using Fluo-4-AM (Thermo Fisher Scientific, F14201) according to the manufacturer’s instructions. Cell cultures were treated with 1 μM cyclopiazonic acid for 30 minutes prior to the start of calcium imaging in order to deplete calcium stores from the endoplasmic reticulum and therefore enable more straightforward detection of calcium influx. At the start of the calcium imaging assay, day 17 iMN/mixed glia cocultures were placed into N3 medium with an additional 1.5 μM glutamate and at least 3 fields per culture were imaged by time lapse for 30 to 60 seconds using a Nikon Ti inverted microscope. Calcium transients per iMN were quantified manually.
Approaches to writing instruction developed in North America have gradually made their presence felt in other parts of the world during recent years. A curricular evaluation of the local needs, instruction, assessments, teacher preparation, and other pedagogical factors is crucial for the successful transmission and integration of those approaches into the new contexts. Set against the background of recent, exuberant scholarly discussions of the issue of transplanting Western writing pedagogies, this article presents an observational report of a typical college English curriculum for non-majors in China, with a focus on its writing component. The study has found that English writing is taught under the guidance of a nationally unified syllabus and examination system. Rather than assisting their students to develop thoughts in writing, teachers in this system are predominantly concerned about the teaching of correct form and test-taking skills. Because of their relatively low economic status in China, English teachers have to work extra hours and have little time to spend on individual students or on furthering their professional training. However, signs of recent Western writing pedagogies, such as pre-writing and multiple-drafting activities, are identified in classrooms and textbook publishing, which indicate the possibility of successful adaptations of the recent Western writing pedagogies in the Chinese context.
“Nuxing yimin de juese: Zhongguo peidu mama zai Xinjiapo” 女性移民的角色:中国陪读妈妈在新加坡 (The Role of Female Migrants: The Role of Study Mamas in Singapore), presented at the conference on “Migration in China and Asia: Experience and Policy,” in Beijing, organized by the Institute of Ethnology and Anthropology, Chinese Academy of Social Sciences, and Metropolis International, 20-21 May 2010.
Xila hé wo nénggòu taolùn you zhengyì de huàtí. Lìrú, women zhenglùn zhongzú. Ta shouxian shengcheng, kè lóu batè la shìgè you cáihuá de heirén fùnu. Wo shuo ta shì cóng bái xilà rén de hòuyì. Hòulái, xila liaojie dào, kè lóu batè la yijing jiéhunle ta dí gege, ye kenéng shì yigè dàng fù. Báirén keyi yongyou ta women zhenglùn zhongzú, zongjiào, zhèngzhì deng deng. Xila xiang chéngwéi yi míng zuòjia. Ta de muqin tóngshí zhàogù xila de háizi.
Zhu Youjian was the fifth son of Zhu Changluo, the Taichang Emperor, and one of his low-ranking concubines, Lady Liu. When Zhu Youjian was four years old, his mother was executed by his father for reasons unknown and was buried secretly. Zhu Youjian was then adopted by his father's other concubines. He was first raised by Consort Kang, and after she adopted his eldest brother Zhu Youxiao, he was raised by Consort Zhuang.
Wang, Y., Fang, L. (2008). Yingyu yuedu jiaolv, yuedu celue he yuedu chengji xiangguanxing yanjiu [A study on the correlation among English reading anxiety, reading strategies, and reading performance]. Chongqing Keji Xueyuan Xuebao (Shehui Keyue Ban) [Journal of Chongqing University of Science and Technology (Social Sciences Edition)], 9, 221–222.Google Scholar
Oct. 2019: Trung Vu is awarded the Best Student Paper Award (second prize) at IEEE International Workshop on Machine Learning for Signal Processing, October 13-16, 2019 Pittsburgh, PA, USA! The award is given to a collaborative paper of Trung Vu, Raviv Raich and Xiao Fu titled ‘‘On Convergence of Projected Gradient Descent for Minimizing a Large-scale Quadratic over the Unit Sphere’’. Congratualations, Trung!

Zongzhi, xila chéngle wo de xin nu péngyou. Ta xiàng wo tongbàole jiànzhú zhong fashengle shénme. Wo shì yigè zhong nián báirén, chuli yigè hen hei de kèhù. Ta shì wo zài wéixian dì dìfang de chàngdao zhe. Dú yin zhe xianrán rènwéi wo you henduo qián. Xila hòulái gàosù wo, zhège jiànzhú wù zhòng taolùn de jìhuà shì qiangjié shènzhì sha si wo de. Bùguò, ta zìji jìxù shiyòng dúpin, ta youshí cóng wo shenshang ná qián yanghuo. Qíta de ye dapòle wo de fángzi tou qián huò qíta cáichan. Cóng 1950 niándài yilái, wo yongyou de yixie ouzhou yìngbì hé huòbì xiaoshile.
Our data indicate that motor neurons derived from C9ORF72 and at least a subset of sporadic ALS patients share similar defects in autophagosome formation and glutamate receptor accumulation. Importantly, PAR1 activation by 3K3A-APC can reverse these C9ORF72 and sporadic ALS disease processes in vitro and in vivo (Figure 7). We draw several key conclusions from our findings.
Jan. 2019, Check out the new paper: ‘‘Learning Nonlinear Mixtures: Identifiability and Algorithm’’. In this work we push forward parameter identifiability of linear mixture models (LMM) to nonlinear ones. LMM finds many applications in blind source separation-related problems, e.g., hyperspectral unmixing and topic mining. In practice, however, the mixing process is hardly linear. This work studies a fundamental question: if there is nonlinearity imposed upon an LMM, can we still identify the underlying parameters of interest? The interesting observation of our work is that: under some conditions, nonlinearity can be effectively removed and the problem will boil down to an LMM identification problem — for which we have tons of tools to handle.
Wo zuìhòu yicì yu zhulì'an dì huìmiàn hen qíguài. Zhè shì zài 2011 nián 2 yuè de dì èr gè xingqí. Ji gè yuè li, wo hái méiyou kàn dào ta, ye méi ting shuoguò ta. Ta kenéng yijing qùle dé kè sà si zhou yiduàn shíjian. Wúlùn rúhé, dang wo shuìzhe de shíhòu, wo zaochén 3 dian cái jie dào diànhuà. Zhulì'an ràng wo zài gelúnbiya gaodì, dàyue wushí hé zhongyang dàdào yùjiàn ta. Ta shuo ta xuyào cóng nàli dào ta muqin zài shèngbaoluó dì dìfang. Qichu wo shuo “bù”le. Wo bùzàihu nàme qingxing de daraole. Dànshì bìjìng shì zhulì'an. Wo da diànhuà shuo wo huì zài nàli.

Wo de yuànwàng de zìsi bùfèn shì ràng yigè háizi cóng wo shenshang yíchuán xiàlái. Wo juédé zhè hen zhòngyào - yexu shì yinwèi wo yiwéi wo zài yíchuán shàng bi qíta rén gèng hao? Bi chángjiu cúnzài gèng hao de xiangfa. Tongguò yigè háizi, wo si hòu huì cúnzài yidìng de chéngdù. Zài shengwù xué shàng, wo de shenghuó jiang huì zhòngyào. Jíshi wo de háizi zài wo zou liao zhihòu bìng méiyou baoliú huò zunzhòng wo de jìyì, suoyi wo yongyuan bù huì wánquán cóng xià yidài hé hòulái de rén zhong tuolí chulái. Shì de, xiang yào jianchí zìji de shenfèn, you yidian shì zìsi de, ér bùshì zhenzhèng zhòngyào de yidian.
6 J.J. Kennedy, “Maintaining popular support for the Chinese Communist Party: the influence of education and the state-controlled media,” Political Studies, Vol. 57, No. 3 (2009), pp. 517–36; Chen, X. and Shi, T., “Media effects on political confidence and trust in the People's Republic of China in the post-Tiananmen period,” East Asia: An International Quarterly, Vol. 19, No. 3 (2001), pp. 84–118.
Wénlín yì wéi “qúnyīng huì” yǔ gōngsī míng xiāngtóng de shì, Wénlín Yánjiūsuǒ de chéngxùyuán dàitóurén dōu shì shēnjiān Hànyǔ yǔyánxuéjiā hé jìsuànjī kēxué gōngchéngshī liǎng zhǒng shēnfèn. Guānchá děngshì liǎngbiān, zhè ràng Wénlín Yánjiūsuǒ de chuàngshǐrén hé zǒngcái Tuōmǎsī E. Bìxiǎopǔ (Thomas E. Bishop) chóngxīn fāxiàn le Hànyǔ shénmì de 36 bǐ “zìmǔ”, jìn'ér yīláoyǒngyì de jiějué le Unicode “quēzì” de wèntí. Zhèxiē chuántǒng jiǎoběn yuánsù yīzhí yǐlái dōu bèi ruǎnjiàn kāifāzhě suǒ hūshì. “CDL yīzhí shì Wénlín de yī bùfèn, dàn wǒmen wèi fāxiàn qiánzài yǔyán, zhídào Wénlín 4.0 bǎn tuīchū. Rújīn yònghù kěyǐ chákàn bìng cāokòng rènhé kě zài bǐhuà kuàng zhōng chákàn de zìfú de CDL miáoshù,” Bìxiǎopǔ shuōdào. Wénlín Yánjiūsuǒ shì Unicode Xiéhuì de róngyù huìyuán, zì 2000 nián yǐlái yīzhí zhìlìyú míhé CJK shùjù chǔlǐ shang de chājù.
This article introduces child-raising blogs in China. Written by mothers and their 6- to 12-year-old offspring, child-raising blogs contain diverse material from and about a child’s daily life and issues relating to a mother raising her offspring. Six blogs from mothers and their daughters are studied under the aspect of generational relations and the voice of children online with the aim of understanding whether or how child-raising blogs in China are part of a changing discourse about the mother-daughter relationship. The article finds that as the objectified state of cultural capital, blogs present a smoothed-out hierarchical relationship between mother and daughter, and carry the possibility of bestowing a voice on children. Due to their continuous and permanent structure, which records opinions and content deemed important by the authors, blogs could be a catalyst or at least a magnifying lens for changes that are already occurring in family relations offline.

While the Chongzhen Emperor was not especially incompetent by the standards of the later Ming, he nevertheless sealed the fate of the Ming dynasty. In many ways, he did his best to save the dynasty. However, despite a reputation for hard work, the emperor's paranoia, impatience, stubbornness and lack of regard for the plight of his people doomed his crumbling empire. His attempts at reform did not take into account the considerable decline of Ming power, which was already far advanced at the time of his accession. Over the course of his 17-year reign, the Chongzhen Emperor executed seven military governors, 11 regional commanders, replaced his minister of defence 14 times, and appointed an unprecedented 50 ministers to the Grand Secretariat (equivalent to the cabinet and chancellor).[23] Even though the Ming dynasty still possessed capable commanders and skilled politicians in its dying years, the Chongzhen Emperor's impatience and paranoid personality prevented any of them from enacting any real plan to salvage a perilous situation.

As an alternative to the 7F iMN differentiation procedure used in Fig. 7 and S8, iMNs were differentiated from C9-ALS and control iPSC lines using a Dox-NIL system. (a, b) Survival of Dox-NIL iMNs with or without TMX2 reduction by shRNA transduction. Results from two control (a) or two C9-ALS (b) lines were averaged to create the survival curves shown. (c, d) The same iMN data depicted in (b) but separated by individual C9-ALS cell line to show the variability in responses. (e) Representative images of GFP+ (shRNA expressing) C9-ALS iMNs taken during the survival experiments. (f) RNA was harvested from iMN survival experiments at the endpoint and TMX2 mRNA levels were measured by qRT-PCR (normalized to GAPDH levels). For information on the patient lines used and numbers of iMNs analyzed for survival analysis, see Supplementary Table 4.
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